WHY LYMPHOCYTES CAN MIGRATE FREELY IN THE LYMPHOID ORGANS?

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It is well known that adhesive substances such as cadherin are participated in the cell-cell contact. However, it is not clear whethrer the lymphocytes which function in the lymphoid organs, or bone marrow, thymus, lymph node, and spleen, and circulate freely in the blood express such adhesive substances.In the present study, the rat thymus was fragmented in Hanks solution and centrifuged. The supernatant was cultured with adhesive hepatoma cell line. As a result, hepatoma cells contact with each other, but didn't with dish surface, or substrate, suggesting that spreading-inhibiting factors may be contained in the supernatant.I would like to promote the study on tenascin which is a large extracellular matrix protein expressed in tissues of the immune system, including the bone marrow, thymus and the T cell areas of secondary lymphoid organs, and plays an important role as an adhesive inhibitor.