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Increase of muscle fiber number induced by spontaneous running exercise

自发跑步运动引起的肌纤维数量增加

基本信息

批准号：
07670094
负责人：
TANAKA Noriko
金额：
$ 0.7万
依托单位：
Kobe Women's University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1995
资助国家：
日本
起止时间：
1995 至 1996
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07670094/
关键词：
sartorius muscle muscle fiber number spontaneous exercise running exercise tapering fiber muscle hypertrophy muscle fiber hyperplasia 筋線維の大きさ縫工筋筋線維形態自然運動

项目摘要

The effect of spontaneous running exercise, which induced muscular enlargement, on fiber number was studied using female weaning rats. Animals were randomly assigned to either an exercising (E) group or a sedentary control (C) group. Exercising animals were placed in steel cages free access to running wheel for spontaneous exercise. After 7 weeks of exercise, muscle weights i.e., heart, gastrocnemius, quadriceps and sartorius increased significantly in E group. Muscle fiber number was investigated in sartorius of which most fibers run the length of each fascicle from its origin to insertion. Sartorius, long muscle, was divided into several sections for the investigation. Fiber number was counted through profile projector by two persons isolating each single fiber under a dissecting microscope after nitric acid tratment.In another different approach, fiber number was counted on photomicrographs of the transverse sections of the muscle. The two approaches confirmed significant increase o … More f fiber number in enlarged muscle following spontaneous running exercise.Fiber number varied in different regions of the muscle, showing the peak of number in the middle of sartorius and decreasing number in regions closest to the origin and insertion. In the middle of the muscle, the total fiber number of exercised muscle increased significantly as compared with control muscle, although muscle fiber area did not change. On the other hand, in the regions of origin and insertion of the muscle, fiber area of E group increased significantly but the total fiber number did not change. There appeared many small fibers in the middle of exercised muscle, which was found to be tapering fiber under a differential interference microscope. DNA and RNA contents in E group were much more than those in C group, espeially in the middle of the muscle. Thus, we concluded that muscle hypertrophy was attributed to increased fiber number in the middle of the muscle and increased fiber area in regions of the origin and insertion, being supported by the biochemicala data. Further, an interference microscopy demonstrated that increase of fiber number in the middle was partly due to appearance of tapering fiber. Less

利用断乳雌性大鼠研究了自发跑步运动对肌肉纤维数量的影响。动物被随机分配到运动（E）组或久坐对照（C）组。将运动动物置于钢笼中，自由接近转轮进行自发运动。经过7周的锻炼，肌肉重量，即，E组心脏、腓肠肌、四头肌、缝匠肌均明显增加。对缝匠肌肌纤维的数量进行了研究，发现缝匠肌肌纤维从起始点到附着点的长度最长。缝匠肌是一种长肌，被分成几个部分进行研究。硝酸处理后，由两个人在解剖显微镜下分离每一根纤维，通过轮廓投影仪计数纤维数量。这两种方法证实， ...更多信息 f自发跑步运动后增粗肌肉中纤维数量的变化，肌纤维数量在缝匠肌中部最多，在靠近起点和止点的区域逐渐减少。在肌肉中部，运动肌肉的总纤维数与对照肌肉相比显著增加，但肌纤维面积没有变化。另一方面，在肌肉的起始和附着区域，E组的纤维面积显著增加，但总纤维数没有变化。在微分干涉显微镜下观察到运动肌中部出现许多细小纤维，呈锥形。DNA和RNA含量E组明显高于C组，尤其是肌肉中部。因此，我们得出结论，肌肉肥大是由于增加的纤维数量在中间的肌肉和增加的纤维面积的区域的起源和插入，被支持的生化数据。此外，干涉显微镜表明，在中间的纤维数量的增加，部分是由于锥形纤维的外观。少