Immunohistochemical Study of Hepatitis Associated Bile Duct Damage in Chronic Hepatitis C,Contrasted with Chronic Bile duct Damage of Primary Biliary Cirrhosis

慢性丙型肝炎相关胆管损伤的免疫组织化学研究及与原发性胆汁性肝硬化慢性胆管损伤的对比

基本信息

  • 批准号:
    07670197
  • 负责人:
  • 金额:
    $ 1.47万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 财政年份:
    1995
  • 资助国家:
    日本
  • 起止时间:
    1995 至 1996
  • 项目状态:
    已结题

项目摘要

We investigated histologically and immunohistochemicaly the differences between hepatitis associated bile duct damage in chronic hapetitis C and chronic non-supprative destructive cholangitis in primary biliary cirrhosis. Histologically, the former was associated with formation of lymphfollicles, in contrast, the latter was associated with eosinophilic infiltration and granulomatous reaction. Immunohistochemically, the expression profile of apomucins (MUC1, MUC2, MUC3 and MUC5/6) and cytokines (IL-1 alpha, IL-1 beta, IL-2, IL-4, IL-5, IL-8, IFN gamma, TNF alpha, TNF beta) showed differences and similarities respectively. The results suggested the different sequence in the two types of bile duct damage.Recentry, we experinenced an autosomal recessive mutant mouse named aly/aly mouse that lacks systemic lymph nodes and also a variable lymphoid cell infiltration with lymph follicles formation in the portal tract, and variable damages in the intrahepatic biliary epithelial cells including pseudopyloric gland metaplasia and proliferative changes. Some of these lesions were reminiscent of primary biliary cirrhosis. In addition, extrahepatic bile duct and intrahepatic large bile duct contained acidophilic substance in their epithelial cytoplasm. Aly/aly mouse may be a good animal model to analyze the metabolism of the biliary substances, and immune-mediated bile duct damages may be produced in this model by immunological modulations. So we go on the investigation.
我们通过组织学和免疫组化研究了慢性丙型肝炎和原发性胆汁性肝硬化慢性非支持性破坏性胆管炎肝炎相关性胆管损伤的差异。组织学上,前者与淋巴滤泡的形成有关,后者与嗜酸性粒细胞浸润和肉芽肿反应有关。免疫组化结果显示,apomucins (MUC1、MUC2、MUC3和MUC5/6)和cytokines (IL-1 α、IL-1 β、IL-2、IL-4、IL-5、IL-8、IFN γ、TNF α、TNF β)的表达谱分别具有差异性和相似性。结果提示两种类型的胆管损伤顺序不同。最近,我们研究了一只常染色体隐性突变小鼠aly/aly小鼠,该小鼠缺乏全身性淋巴结,并且在门静脉形成淋巴滤泡的变异性淋巴样细胞浸润,肝内胆道上皮细胞的变异性损伤,包括假幽门腺化生和增生性改变。其中一些病变使人想起原发性胆汁性肝硬化。此外,肝外胆管和肝内大胆管上皮细胞质中含有嗜酸物质。Aly/ Aly小鼠可能是分析胆道物质代谢的良好动物模型,该模型可能通过免疫调节产生免疫介导的胆管损伤。所以我们继续调查。

项目成果

期刊论文数量(11)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
M.Sasaki, Y.Nakanuma: "Frequent expression of MUCI apomucin on biliary epithelial cells of damaged small bille ducts in primary biliary cirrhosis and chronic viral hepatitis : An immunohistochchemical study" Hepatology. 23 (6). 1313-1317 (1996)
M.Sasaki,Y.Nakanuma:“原发性胆汁性肝硬化和慢性病毒性肝炎中受损小胆管胆管上皮细胞上 MUCI 载脂蛋白的频繁表达:一项免疫组织化学研究”肝病学。
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
Masahiro Hoso,et al.: "Granlomatone chalangitis in chromic hepatitis C:A new diagnostic problem in liver pothology" Pathology International. 46. 301-305 (1996)
Masahiro Hoso 等人:“慢性丙型肝炎中的肉芽肿性毛细管炎:肝脏病理学的新诊断问题”国际病理学。
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
Y.Nakanuma, K.Tsuneyama, N.Kono, M.Hoso, J.Van de Water, ME.Gershwin: "Biliary epithelial expression of pyruvate dehydrogenase complex in primary bilary cirrhosis : An Immunohistochemicaland immunoelectron microscopic study" Hum Pathol. 26. 92-98 (1995)
Y.Nakanuma、K.Tsuneyama、N.Kono、M.Hoso、J.Van de Water、ME.Gershwin:“原发性胆汁性肝硬化中丙酮酸脱氢酶复合物的胆道上皮表达:免疫组织化学和免疫电子显微镜研究”Hum Pathol。
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

HOSO Masahiro其他文献

HOSO Masahiro的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('HOSO Masahiro', 18)}}的其他基金

Mechanism of pathological changes of the sciatic nerve tissue during contracture and examination on physical treatment. A histological and immunohistological study.
坐骨神经组织挛缩时的病理变化机制及理疗检查。
  • 批准号:
    15K01412
  • 财政年份:
    2015
  • 资助金额:
    $ 1.47万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Influence of nerve system to the histopathological changes of joint contracture. A study using experimental spinal cord injury model in rat.
神经系统对关节挛缩组织病理学变化的影响。
  • 批准号:
    23500581
  • 财政年份:
    2011
  • 资助金额:
    $ 1.47万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Histopatholgical change of soft tissue and effect of physical therapy during joint contracture
关节挛缩时软组织的组织病理学变化及物理治疗效果
  • 批准号:
    20500444
  • 财政年份:
    2008
  • 资助金额:
    $ 1.47万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)

相似海外基金

Evaluating the impact of direct-acting antiviral treatment access policy on chronic hepatitis C prevalence and the undiagnosed proportion
评估直接抗病毒治疗获取政策对慢性丙型肝炎患病率和未确诊比例的影响
  • 批准号:
    475136
  • 财政年份:
    2022
  • 资助金额:
    $ 1.47万
  • 项目类别:
    Operating Grants
Search for novel biomarkers involved in hepatocarcinogenesis and liver fibrosis in patients with chronic hepatitis C
寻找参与慢性丙型肝炎患者肝癌发生和肝纤维化的新型生物标志物
  • 批准号:
    20K16956
  • 财政年份:
    2020
  • 资助金额:
    $ 1.47万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Evaluation for the liver fibrosis and hepatocellular carcinoma incidence after HCV elimination in patients with chronic hepatitis C
慢性丙型肝炎患者消除HCV后肝纤维化及肝癌发生率评估
  • 批准号:
    20K08820
  • 财政年份:
    2020
  • 资助金额:
    $ 1.47万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Analysis of immune responses in patients with chronic hepatitis C after viral clearance
慢性丙型肝炎患者病毒清除后的免疫反应分析
  • 批准号:
    19K17509
  • 财政年份:
    2019
  • 资助金额:
    $ 1.47万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Impact of chronic hepatitis C virus (HCV) direct-acting antiviral therapy on extrahepatic manifestations among HIV co-infected British Columbians engaged in clinical care
慢性丙型肝炎病毒 (HCV) 直接抗病毒治疗对从事临床护理的 HIV 合并感染不列颠哥伦比亚省人肝外表现的影响
  • 批准号:
    391545
  • 财政年份:
    2018
  • 资助金额:
    $ 1.47万
  • 项目类别:
Medicaid Prior Authorization Policies for Chronic Hepatitis C Treatment in Vulnerable Populations
针对弱势群体慢性丙型肝炎治疗的医疗补助预授权政策
  • 批准号:
    10395933
  • 财政年份:
    2018
  • 资助金额:
    $ 1.47万
  • 项目类别:
Medicaid Prior Authorization Policies for Chronic Hepatitis C Treatment in Vulnerable Populations
针对弱势群体慢性丙型肝炎治疗的医疗补助预授权政策
  • 批准号:
    9906205
  • 财政年份:
    2018
  • 资助金额:
    $ 1.47万
  • 项目类别:
Real-world effectiveness of direct-acting antiviral therapy for chronic hepatitis C among HIV co-infected Canadians receiving clinical care
直接作用抗病毒治疗对接受临床护理的艾滋病毒合并感染加拿大人慢性丙型肝炎的真实效果
  • 批准号:
    368162
  • 财政年份:
    2017
  • 资助金额:
    $ 1.47万
  • 项目类别:
Ezetimibe as a Safe and Efficacious Treatment for Chronic Hepatitis C
依折麦布作为慢性丙型肝炎安全有效的治疗方法
  • 批准号:
    10158395
  • 财政年份:
    2017
  • 资助金额:
    $ 1.47万
  • 项目类别:
Population-level impact of direct-acting antiviral (DAA) therapies for chronic hepatitis C on extrahepatic manifestations
直接作用抗病毒(DAA)治疗慢性丙型肝炎对肝外表现的人群影响
  • 批准号:
    375866
  • 财政年份:
    2017
  • 资助金额:
    $ 1.47万
  • 项目类别:
    Fellowship Programs
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了