The study of characterization and tumor cell origin of natural killer (NK) cell lymphoma.

自然杀伤（NK）细胞淋巴瘤的特征和肿瘤细胞起源的研究。

• 批准号: 07670224
• 负责人: SUZUMIYA Junji
• 金额: $ 0.51万
• 依托单位: Fukuoka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07670224/
• 关键词: Malignant lymphoma; Nasal lymphoma; NK cell; EB virus; TdT; Lymphoblastic lymphoma; Cutaneous lymphoma; 悪性リンパ腫Malignant lymphoma; ナチュラルキラー細胞Natural Killer cell (NK) cell; CD56 (NCAM); EBウイルスEB virus; 鼻腔リンパ腫Nasal lymhoma

1. The majority of nasal lymphoma was considered to be of T cell lineage because of the expression of T cell markers. However, recently we and some researchers showed no rearrangement of T cell receptors (TCRs) genes and the expression of CD56 in the lymphoma and categorized the lymphoma as NK/T cell origin. The NK/T nasal lymphomas have some characteristics of the fetal and adult type of NK cell. The NK/T nasal lymphoma is strongly associated with Epstein-Barr virus (EBV). We analyzed 33 cases with nasal lymphoma and 12 cases with pharyngeal lymphoma and revealed that the nasal NK/T cell lymphoma is the different group from those of nasal B cell, or pharyngeal T- and B-cell lymphomas, because of the expression of CD56 and silent TCR and the monoclonal infection of EBV of the tumor cells with the thistological sharacteristics such as angiocentric and/or angiodestructive patterns, necrosis, polymorphic nuclear contours and azurophilic granules in the lymphoma cells.2. The newly developed immunostain of terminal deoxynucleotidyl transferase (TdT) on paraffin sections is very useful for the diagnosis of lymphoblastic lymphoma. We detected the presence of lymphoblastic type of NK/T cell lymphoma, confirmed by this method. This lymphoblastic lymphoma is the immature type of the nasal NK/T cell lymphoma and is not associated. with EBV.3. The NK/T cell lymphoma is found also among the subcutaneous proliferation of tumor cells of large round nuclei, which occasionally demonstrate EBV infection.

1. 由于T细胞标记物的表达，大多数鼻淋巴瘤被认为是T细胞谱系。然而，最近我们和一些研究人员发现淋巴瘤中没有T细胞受体（TCRs）基因重排和CD56的表达，并将淋巴瘤归类为NK/T细胞起源。NK/T鼻淋巴瘤具有胎儿型和成人型NK细胞的一些特征。NK/T鼻淋巴瘤与eb病毒（EBV）密切相关。我们分析了33例鼻淋巴瘤和12例咽淋巴瘤，发现鼻腔NK/T细胞淋巴瘤与鼻腔B细胞淋巴瘤、咽T细胞淋巴瘤和咽B细胞淋巴瘤是不同的一类，因为肿瘤细胞表达CD56和沉默的TCR以及EBV的单克隆感染具有血管中心性和/或血管破坏模式、坏死等组织学特征。淋巴瘤细胞的多态核轮廓和亲氮颗粒。新开发的石蜡切片末端脱氧核苷酸转移酶（TdT）免疫染色对淋巴母细胞淋巴瘤的诊断有重要意义。我们检测到淋巴母细胞型NK/T细胞淋巴瘤的存在，用这种方法证实。这种淋巴母细胞淋巴瘤是鼻NK/T细胞淋巴瘤的未成熟型，与鼻NK/T细胞淋巴瘤无关。EBV.3。NK/T细胞淋巴瘤也见于大圆核肿瘤细胞的皮下增生，偶尔表现为EBV感染。

项目成果

Takeshita, M., Akamatsu, M., Ohshima, K. et al.: "Angiocentric immunoproliferative lesions of the skin show lobular panniculitis and are mainly disorders of large granular" Human Pathology. 26. 1321-1328 (1995)

Takeshita, M.、Akamatsu, M.、Ohshima, K. 等人：“皮肤的血管中心性免疫增殖性病变显示小叶性脂膜炎，主要是大颗粒疾病”人类病理学。

Takeshita,M.et al.: "Angiocentric immunoproliferative lesions of the skin show lobular panniculitis and are mainly disorders of large granular lymphocytes." Human Pathology. 26. 1321-1328 (1995)

Takeshita,M.等人：“皮肤的血管中心性免疫增殖性病变表现为小叶性脂膜炎，主要是大颗粒淋巴细胞的疾病。”

Koita H,Suzumiya J.et al.: "Lymphoblastic lymphoma expressing natural killer cell phenotype with involvement of the mediastinum and nasal cavity." The American Journal of Surgical Pathology. 21(2). 242-248 (1997)

Koita H、Suzumiya J.等人：“表达自然杀伤细胞表型的淋巴母细胞淋巴瘤，累及纵隔和鼻腔。”

Suzumiya,J.et al.: "TCR(-)CD56(+)CD2(+) nasal lymphomas with membrane-localized CD3 positivity : Are the CD3(+) cells neoplastic or reactive? Response." Blood. 85. 2994-2996 (1995)

Suzumiya,J.et al.：“具有膜局部 CD3 阳性的 TCR(-)CD56( )CD2( ) 鼻淋巴瘤：CD3( ) 细胞是肿瘤性的还是反应性的？反应。”

Suzumiya, J., Ohshima, K., Kikuchi, M.: "The association of Epstein-Barr virus (EBV) with T cell lymphoma. (in Japanese)" Hemotology and Oncology. 32 (6). 500-507 (1996)

Suzumiya, J.、Ohshima, K.、Kikuchi, M.：“EB 病毒 (EBV) 与 T 细胞淋巴瘤的关联。（日语）”血液学和肿瘤学。