Possibility of new endstopic pbotodynamic therapy with ultrasound.

超声新的终点光动力疗法的可能性。

• 批准号: 07670636
• 负责人: TOMITA Akira
• 金额: $ 1.34万
• 依托单位: Fukuoka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07670636/
• 关键词: photodynamin therapy; Photofrin II; endoscopy; Ultrasound; colon 26; 超音波; 消化器癌

Ultrasound has been used extensively over the last decades for medical diagnostics and physical therapy. Recently a number of reports have demonstrated enhanced cytotoxic responses when ultrasound and chemotherapeutic agents are combined.Enhancement of acute cell killing of colon26 cells by low-level ultrasound in the presence of the photosensitizing drug Photofrin II was examined by the use of ultra-thin ultrasound probe in vitro. The probe has an outer diameter of 2 mm and fits through the instrument channel of a common endoscope. Photofrin II alone showed no significant cell killing effect but ultrasound alone showed a slight that. The combined ultrasound and Photofrin II showed marked cell killing effect.These results suggest that the possiblity of the new endoscopic photodynamic therapy with ultrasound.

在过去的几十年中，超声已被广泛用于医学诊断和物理治疗。最近的一些报道表明，当超声和化疗药物联合使用时，细胞毒性反应增强。在光敏药物Photofrin II的存在下，低强度超声对colon26细胞的急性细胞杀伤的增强作用通过使用超薄超声探头在体外进行检查。该探头的外径为2 mm，可穿过普通内窥镜的器械通道。单独的Photofrin II没有显示出显著的细胞杀伤作用，但单独的超声显示出轻微的细胞杀伤作用。超声与Photofrin Ⅱ联合应用对肿瘤细胞有明显的杀伤作用，提示超声内镜下光动力治疗肿瘤的可能性。