Understanding How the Hungry Brain Regulates Metabolism

了解饥饿的大脑如何调节新陈代谢

• 批准号: DP220102910
• 负责人: A/Prof Garron Dodd
• 金额: $ 43.16万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-01 至 2025-12-29
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220102910
• 关键词: Understanding; How; Hungry; Brain; Regulates

Energy homeostasis is essential for life as it ensures an adequate supply of fuel to cells of the body. This process is orchestrated by neurons in the hypothalamus of the brain. This project aims to determine the role of the extracellular matrix that surrounds hypothalamic neurons and how this regulates energy homeostasis, an area of science that is completely unexplored. This project expects to identify the composition the extracellular matrix within the hypothalamus and discover how it regulates energy homeostasis. The outcomes of this project are to provide new knowledge in understanding how the brain regulates metabolism, to promote population health & wellbeing, develop new technologies and training the next generation of researchers.

能量平衡是生命的关键，因为它确保了身体细胞的燃料供应充足。这个过程是由大脑下丘脑的神经元协调的。该项目旨在确定围绕下丘脑神经元的细胞外基质的作用以及它如何调节能量稳态，这是一个完全未探索的科学领域。本计画期望能找出下视丘细胞外基质的组成，并发现它如何调节能量平衡。该项目的成果是提供新的知识，了解大脑如何调节新陈代谢，促进人口健康和福祉，开发新技术和培训下一代研究人员。