Understanding How the Hungry Brain Regulates Metabolism

能量平衡对生命是至关重要的，因为它确保了身体细胞的充足燃料供应。这一过程是由大脑下丘脑中的神经元协调的。该项目旨在确定围绕下丘脑神经元的细胞外基质的作用，以及这种作用如何调节能量动态平衡，这是一个完全未被探索的科学领域。该项目希望确定下丘脑细胞外基质的组成，并发现它是如何调节能量平衡的。该项目的成果是提供了解大脑如何调节新陈代谢的新知识，促进人群健康和福祉，开发新技术，并培训下一代研究人员。

Energy homeostasis is essential for life as it ensures an adequate supply of fuel to cells of the body. This process is orchestrated by neurons in the hypothalamus of the brain. This project aims to determine the role of the extracellular matrix that surrounds hypothalamic neurons and how this regulates energy homeostasis, an area of science that is completely unexplored. This project expects to identify the composition the extracellular matrix within the hypothalamus and discover how it regulates energy homeostasis. The outcomes of this project are to provide new knowledge in understanding how the brain regulates metabolism, to promote population health & wellbeing, develop new technologies and training the next generation of researchers.