Dominance relationship and sturess responses in male rhe sus monkeys -as a model of evolutinal and physiological study of psychosomatic disease

我研究了非人类灵长类动物的优势关系与压力反应的关系，作为人类关系中压力反应的模型。方法：1；两只雄性恒河猴在笼子里配对，并在配对前和配对后两小时采集血液样本。检测血液中ACTH、皮质醇和雄激素的含量。2. 配对6天后，将2只动物分离，采集血样测定ACTH和皮质醇。3. CRH刺激试验在动物单独和配对时进行。4. 在一年的时间里，测量了三只猴子在服用CRH后的雄激素和促肾上腺皮质激素的浓度。通过等级检验确定主从地位。结果：1；在接触中，与从属动物相比，优势动物检测到更高水平的ACTH和皮质醇。雄激素的分泌量在优势动物中增加，而在从属动物中减少。2. 分离后ACTH的分泌在优势动物中增高。3. 当动物单独时，给药后ACTH的分泌在优势和从属动物之间无显著差异。但当它们配对时，从属动物的ACTH分泌量低于优势动物。4. 10月血中雄激素浓度最低，促肾上腺皮质激素刺激后促肾上腺皮质激素分泌最高。讨论：本报告表明，支配动物和从属动物在应激反应上存在特征性差异。这些应激反应涉及下丘脑-垂体-肾上腺皮质轴和下丘脑-垂体-睾丸轴，但这两个轴的应激反应之间的直接关系尚不清楚。

I studied, as a model of stress reaction in human relationship, the relation between the dominance relationship and stress reactions in non-human primate.methods : 1. Two male rhesus monkeys were paired in a cage and blood samples were collected before and two hours after pair formation. ACTH,cortisol and androgens in blood samples were measured. 2. After six day's pairing, two animals were separated and blood samples were collected for measuring ACTH and cortisol. 3. CRH stimulation tests were conducted in animals when they were alone and paired. 4. Both concentrations of andorgens and ACTH secretions after CRH administrations were measured during one year for three monkeys. Dominance-subordinate status was ascertained through rank tests.results : 1. In encounters, higher levels of both ACTH and cortisol were detected in dominant animals in comparison to subordinate animals. Secretions of androgens increased in volume in dominant animals but decreased in subordinate animals agter pair formations. 2. Secretions of ACTH after separations increased higher in dominat animals. 3. When animals were alone, there were non significant differences in ACTH secretions after administration of CRH between dominant and subordinate animals. But when they were paired, ACTH secretions in subordinate animals were lower than in dominant animals. 4. Concentrations of andorogens in blood were lowest in October, and ACTH secretions after CRH stimulation were highest in October.discussion : This report shows that there are characteristic differences in stress responses between dominat and subordinate animals. These stress responses involve both hypothalamic-pituitary-adrenocortical axiz and hypothalamic-pituitary-testicular axis but the direct relationship between these two axs stress responses are open question.