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Dominance relationship and sturess responses in male rhe sus monkeys -as a model of evolutinal and physiological study of psychosomatic disease

雄性恒河猴的优势关系和应激反应——作为心身疾病进化和生理研究的模型

基本信息

批准号：
07804062
负责人：
KIMURA Kazumasa
金额：
$ 1.15万
依托单位：
NATIONAL INSTITUTE OF MENTAL HEALTH
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1995
资助国家：
日本
起止时间：
1995 至 1996
项目状态：
已结题

项目摘要

I studied, as a model of stress reaction in human relationship, the relation between the dominance relationship and stress reactions in non-human primate.methods : 1. Two male rhesus monkeys were paired in a cage and blood samples were collected before and two hours after pair formation. ACTH,cortisol and androgens in blood samples were measured. 2. After six day's pairing, two animals were separated and blood samples were collected for measuring ACTH and cortisol. 3. CRH stimulation tests were conducted in animals when they were alone and paired. 4. Both concentrations of andorgens and ACTH secretions after CRH administrations were measured during one year for three monkeys. Dominance-subordinate status was ascertained through rank tests.results : 1. In encounters, higher levels of both ACTH and cortisol were detected in dominant animals in comparison to subordinate animals. Secretions of androgens increased in volume in dominant animals but decreased in subordinate animals agter pair formations. 2. Secretions of ACTH after separations increased higher in dominat animals. 3. When animals were alone, there were non significant differences in ACTH secretions after administration of CRH between dominant and subordinate animals. But when they were paired, ACTH secretions in subordinate animals were lower than in dominant animals. 4. Concentrations of andorogens in blood were lowest in October, and ACTH secretions after CRH stimulation were highest in October.discussion : This report shows that there are characteristic differences in stress responses between dominat and subordinate animals. These stress responses involve both hypothalamic-pituitary-adrenocortical axiz and hypothalamic-pituitary-testicular axis but the direct relationship between these two axs stress responses are open question.

作为人际关系中应激反应的模型，本研究以非人灵长类动物为研究对象，探讨了优势关系与应激反应的关系。两只雄性恒河猴在笼中配对，并在配对前和配对后两小时收集血液样品。测定血中ACTH、皮质醇和雄激素。2.配对6天后，将两只动物分开，采集血样用于测定ACTH和皮质醇。3. CRH刺激试验在动物单独和配对时进行。4.在一年的时间内，对三只猴子在CRH给药后的促肾上腺激素和促肾上腺皮质激素分泌物的浓度进行了测定。通过秩和检验确定了主-从关系。在遭遇，较高水平的促肾上腺皮质激素和皮质醇被检测到占主导地位的动物相比，下属动物。雄激素的分泌量在优势动物中增加，而在从属动物中减少。2.分离后ACTH的分泌量在优势动物中增加更高。3.当动物单独时，CRH给药后，优势动物和从属动物的ACTH分泌无显著差异。但当它们配对时，从属动物的ACTH分泌量低于优势动物。4. 10月份血液中雄激素浓度最低，CRH刺激后ACTH分泌量最高。讨论：本报告表明，在应激反应中，优势动物和从属动物之间存在特征性差异。这些应激反应涉及下丘脑-垂体-肾上腺皮质轴和下丘脑-垂体-睾丸轴，但这两个轴的应激反应之间的直接关系是未知的。