Dominance relationship and sturess responses in male rhe sus monkeys -as a model of evolutinal and physiological study of psychosomatic disease

作为人际关系中应激反应的模型，研究了非人类灵长类动物的显性关系与应激反应之间的关系。方法：1.将两只雄性恒河猴在笼子里配对，并在配对前和配对后2小时采集血样。测定血样中ACTH、皮质醇和雄激素水平。2.配对6天后，分离两只动物，采集血样测定ACTH和皮质醇。3.动物单独和配对时进行CRH刺激试验。4.对三只猕猴进行了一年的雄激素浓度和促肾上腺皮质激素释放量的测定。结果：1.在相遇中，优势动物的ACTH和皮质醇水平均高于从属动物。在配对形成后，优势动物的雄激素分泌量增加，而从属动物的雄激素分泌量减少。2.优势动物分离后ACTH分泌量增加较多。3.单独给予CRH后，优势动物与从属动物之间的ACTH分泌无显著差异。但当它们配对时，从属动物的ACTH分泌低于优势动物。4.血中雄激素浓度在10月份最低，促肾上腺皮质激素释放激素分泌在10月份最高。讨论：本报告显示了优势动物和从属动物在应激反应上的特征差异。这些应激反应既涉及下丘脑-垂体-肾上腺皮质轴，也涉及下丘脑-垂体-睾丸轴，但这两种应激反应之间的直接关系尚无定论。

I studied, as a model of stress reaction in human relationship, the relation between the dominance relationship and stress reactions in non-human primate.methods : 1. Two male rhesus monkeys were paired in a cage and blood samples were collected before and two hours after pair formation. ACTH,cortisol and androgens in blood samples were measured. 2. After six day's pairing, two animals were separated and blood samples were collected for measuring ACTH and cortisol. 3. CRH stimulation tests were conducted in animals when they were alone and paired. 4. Both concentrations of andorgens and ACTH secretions after CRH administrations were measured during one year for three monkeys. Dominance-subordinate status was ascertained through rank tests.results : 1. In encounters, higher levels of both ACTH and cortisol were detected in dominant animals in comparison to subordinate animals. Secretions of androgens increased in volume in dominant animals but decreased in subordinate animals agter pair formations. 2. Secretions of ACTH after separations increased higher in dominat animals. 3. When animals were alone, there were non significant differences in ACTH secretions after administration of CRH between dominant and subordinate animals. But when they were paired, ACTH secretions in subordinate animals were lower than in dominant animals. 4. Concentrations of andorogens in blood were lowest in October, and ACTH secretions after CRH stimulation were highest in October.discussion : This report shows that there are characteristic differences in stress responses between dominat and subordinate animals. These stress responses involve both hypothalamic-pituitary-adrenocortical axiz and hypothalamic-pituitary-testicular axis but the direct relationship between these two axs stress responses are open question.