Studies for pathogenesis of erythema migrans caused by Lyme disease Borrelia

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This study describes a role of platelet-activating factor (PAF) as a potential inducer of inflammation in infection with Borrelia burgdorferi. Following approaches were done.1) The first involved the use of a PAF antagonist to show the lack of an inflammatory response in skin lesions.2) The second was to show that the PAF antagonist reduced platelet aggregation when the spirochetes were incubated with polymorphonuclear leukocytes (PMN).3) The third was to show that the PMN,which were activated by the spirochetes, inhibited collagen-platelet aggregation.3) The forth was to show the effect of spirochetes on the adherence of platelets and PMN to cultured human umbilical vein endothelial cells (HUVEC). The PAF antagonist reduced the cell-adherence to HUVEC.These observations may contribute to a better underestanding of the pathogenesis of Lyme disease spirochetes in the local inflammatory reaction.