AZELATINE EFFECT ON RADIATION DERMATITIS

氮杂碱对放射性皮炎的作用

• 批准号: 07807086
• 负责人: BABA Yuji
• 金额: $ 1.15万
• 依托单位: KUMAMOTO UNIVERSITY HOSPITAL
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07807086/
• 关键词: Azelastine; Radiation injury; Radiation dermatitis; Mouse skin; Mouse tumor; マウス

Purpose : In our previous report we described the clinical value of azelastine, an oral antiallergic agent, as an inhibitor of radiation dermatitis. We studied here the effect of azelastine on the normal skin and tumor size after irradiation in a mice model.Methods and Materials : The modifying effects of azelastine on both the degree of radiation dermatitis and antitumoral effect of radiation therapy were investigated in the normal skin as well as in SCC VII tumors of C3H/He mice. The right hind legs with or without bearing tumors were irradiated with 20-60 Gy at 0.62 Gy/min. Azelastine was added to the chow. Acute skin reactions and tumor growth curves were compared between the azelastine and control groups.Results : The acute skin reactions of the azelastine group were significantly less prominent than those of the control group (p<0.01). At a dose of 40 Gy the dose modification factors were 1.19-1.25. The tumor growth curves of the azelastine and control groups were almost identical, indicating that the treatment response of irradiation was not affected by administration of azelastine.Conclusions : Application of azelastine reduces the degree of acute radiation dermatitis without affecting the antitumoral effect of radiation therapy.

目的：在我们之前的报告中，我们描述了氮卓斯汀（一种口服抗过敏药）作为放射性皮炎抑制剂的临床价值。我们在小鼠模型中研究了氮卓斯汀对辐射后正常皮肤和肿瘤大小的影响。方法和材料：在正常皮肤以及 C3H/He 小鼠的 SCC VII 肿瘤中研究了氮卓斯汀对放射性皮炎程度和放射治疗的抗肿瘤效果的改变作用。用20-60Gy以0.62Gy/min照射具有或不具有肿瘤的右后腿。将氮卓斯汀添加到食物中。比较氮斯汀组和对照组的急性皮肤反应和肿瘤生长曲线。结果：氮斯汀组的急性皮肤反应明显低于对照组(p<0.01)。剂量为 40 Gy 时，剂量修正系数为 1.19-1.25。氮卓斯汀组和对照组的肿瘤生长曲线几乎相同，表明氮卓斯汀的给药不影响放射治疗反应。结论：氮卓斯汀的应用减轻了急性放射性皮炎的程度，且不影响放射治疗的抗肿瘤效果。

项目成果

Furusawa M: "Azelastine : Clinical application in radiation dermatitis." Radiology. 193(P). 309 (1994)

Furusawa M：“氮卓斯汀：放射性皮炎的临床应用。”

Ryuji Murakami: "Effect of Azelastine on Acute Radiation Dermatitis in Mice Model." International Journal of Radiation Oncology, Biology,Physics.

Ryuji Murakami：“氮卓斯汀对小鼠模型急性放射性皮炎的作用。”

村上龍次: "塩酸アゼラスチンの放射線防護効果についての基礎的検討" 日本医学放射線学会雑誌. 55(2). S116 (1995)

Ryuji Murakami：“盐酸氮卓斯汀的辐射防护作用的基础研究”日本医学放射学会杂志55（2）（1995）。

Ryuji Murakami: "The Effect of Azelastine on Acute Radiation Dermatitis in Mice Model." International Journal of Radiation Oncology, Biology, Physics. 37-4 (in press). (1997)

Ryuji Murakami：“氮斯汀对小鼠模型急性放射性皮炎的作用。”

Ryuji Murakami: "Effect of Azelastine on Acute Radiation Dermatitis in Mice Model." International Journal of Radiation Oncology,Biology,Physics.

Ryuji Murakami：“氮卓斯汀对小鼠模型急性放射性皮炎的作用。”