The expression of Immediate Eearly Gene (IEG) during development.

为了验证脑电反应在突触可塑性中的假设作用以及癫痫发生过程中异常可塑性的形成，我们研究了El小鼠（一种众所周知的癫痫突变模型）脑电的表达。本研究发现，在相同的癫痫阈值条件下，zif在癫痫发作后30分钟在大脑和小脑中表达最多。没有地区差异。结合癫痫发作史检查结果表明，在边缘系统中，频繁发作时最大表达位点从梨状皮质和内嗅皮质转移到齿状回，并进一步转移到海马CA3和CA1。另一方面，随着发育的结果表明，通过发育和反复发作，c-fos的表达位点逐渐从海马的主要输入系统转移；即梨状皮质，内嗅皮质和齿状回，到海马CA1。研究还表明，顶叶皮层的表达位点最初是局部的，然后变得普遍。进一步证明，该表达位点最终在整个皮质中变得普遍而弱。

To examine the hypothesized role of the IEG response in synaptic plasticity and further the formation of abnormal plasticity in epileptogenesis, we studied the expression of IEGs in El mice, a well known mutant model of epilepsy.In the present study, it was obserbed that zif was expressed maximally 30 min after seizure in both cerebrum and cerebellum under the same condition of the seizure threshold. There were no regional differences.Results as examined with seizure history indicate that in the limbic system the maximum expression site shifts from the pyriform cortex and entorhinal cortex to the dentate gyrus and further to ther hippocampal CA3 and CA1 by frequent seizures.On the other hand, results with development indicate that through the development as well as repetitive seizures, the c-fos expression site shifts gradually from the primary input system of the hippocampus ; i.e., the pyriform cortex, entorhinal cortex and dentate gyrus, to the hippocampal CA1. It is also indicated as for the parietal cortex that the expression site is initially localized and then becomes universal. It is further demonstrated that the expression site finally becomes universal and weak in all over the cortex.