ICTOGENESIS AND EPILEPTOGENESIS IN EL MICE

在EL小鼠中，在大约10周龄时已经建立了癫痫发作，而癫痫发作将通过发育期间的重复癫痫发作建立。提示“神经可塑性异常”可能在癫痫的发生和发展中起关键作用，并可能成为癫痫药物治疗的新靶点。据报道，一氧化氮合成酶的一些异构体（nNOS和eNOS）都是建立长时程增强（LTP）现象所必需的。LTP和异常的神经可塑性在脑生理功能的建立和癫痫的发病机制中起着关键作用。为探讨神经可塑性异常在EL小鼠脑内癫痫发生中的作用，本研究采用生物化学和分子生物学方法对癫痫突变体进行了分析。

In EL mice, ictogenesis has been established at around 10 weeks of age, whereas epileptogenesis will be established through experience of repetitive seizures during development. It is suggested that an "abnormal neural plasticity" may play a crucud role in the establishment of Ictogenesis and epileptogenesis, and therefore, can be a potential target for the development of a new pharmacotherapy to the epilepsy. It is reported that some isoforms of nitric oride synthetases (nNOS and eNOS) are both necessary for the establishment of long-term potentiation (LTP) phenomena. LTP and Abnormal neural plasticity will play the key roles in the establishment of physiological brain function and pathogenesis of epileptic disorder. To investigate the role of abnormal neural plasticity in the iictogenesis and epileptogenesis in EL mice brain, epileptic mutant were analized by biochemical and moleclar biological methods.