Protection of silent aspiration in the elderly

保护老年人的沉默愿望

• 批准号: 07838002
• 负责人: SASAKI Hidetada
• 金额: $ 1.47万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07838002/
• 关键词: Cerebral infarction; basal ganglia; silent aspiration; dopamine; substance P; capsaicin; swallowing reflex; pneumonia; カプサイシン

To examine the possible relationship between the location of telencephalic infarctions and the incidence of pneumonia, we retrospectively assessed central nervous system morbidity associated with pneumonia in 276 patients 65 years of age or older admitted to a long-term care facility. Patients involved in this study were monitored to determine if they sustained an affecting telencephalic structures. The average duration of observation for all patients was 22 months, and stroke patients were followed for over one year. The incidence of pneumonia was 2.66 times higher in patients with unilateral basal ganglia infarcts (27.4% ; p<0.01) and 4.56 times higher in patients with bilateral basal ganglia strokes (47.0% ; p<0.001) compared to all the other patient groups combined (10.3%). Since patients with basal ganglia infarcts also had a delayd swallowing reflex associated with a higher incidence of silent aspiration during sleep, we speculate that basal ganglia strokes might predispose these patients to develop pneumonia due to frequent aspiration during sleep.

为了研究端脑梗死位置与肺炎发病率之间的可能关系，我们回顾性评估了276例65岁及以上住院长期护理机构的患者与肺炎相关的中枢神经系统发病率。对参与这项研究的患者进行监测，以确定他们是否持续影响端脑结构。所有患者的平均观察时间为22个月，脑卒中患者随访1年以上。单侧基底节区梗死患者的肺炎发病率是其他组患者的2.66倍（27.4%,p<0.01），双侧基底节区卒中患者的肺炎发病率是其他组患者的4.56倍（47.0%,p<0.001）。由于基底节区梗死患者的吞咽反射延迟与睡眠中无声误吸的发生率较高相关，我们推测基底节区中风可能使这些患者因睡眠中频繁误吸而易患肺炎。

项目成果

R.Kikuchi et al.: "High incidence of silent aspiration in elderly patients with community-aquired pneumonia" Am J Respin Crit Care Med. 150. 251-253 (1994)

R.Kikuchi 等人：“社区获得性肺炎老年患者无声误吸的发生率很高”Am J Respin Crit Care Med。

T.Yoneyama etal: "Oral hygiene reducls respiatery infections in elderly bed-bound ncrsing home pattents." Arch Gerontol Gevatr. 22. 11-19 (1996)

T.Yoneyama 等人：“口腔卫生可减少卧床不起的老人的呼吸道感染。”

T.Nakagawa et al: "Sputum substance P in aspiration pneumonia" Lancet. 345. 1447 (1995)

T.Nakakawa 等：“吸入性肺炎中的痰液 P 物质”《柳叶刀》。

H.Kobayashi et al: "Aging effects on swallowing reflex" Chest. (in press).

H.Kobayashi 等人：“衰老对吞咽反射的影响”胸部。

T.Nakagawa et al: "High mcidence of pneumonia in elderly patients with basal ganglia imfarction." Arch Int Med. (in press).

T.Nakakawa 等人：“患有基底节梗塞的老年患者肺炎发病率很高。”