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Prevention of pneumonia in the elderly

Prevention of pneumonia in the elderly
老年人肺炎的预防
批准号:
13307021
负责人:
SASAKI Hidetada
金额:
$25.71万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (A)
财政年份:
2001
资助国家:
日本
项目状态:
已结题
起止时间:
2001 至 2004

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中文摘要
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英文摘要
Pneumonia in the elderly is caused by an in apparent swallowing disorder. Most suffer silent aspiration, which eventually causes pneumonia. This is due to t lack in substance P, which transmits in an antidromic way through the sensory branches, such as vagal and glossopharyngeal nerves, and deeps swallowing and cough reflex functioning. The synthesis of substance P is stimulated by dopamine that is released from the deep cortex in the cerebrum. When there is a shortage of dopamine, widely used in the treatment of Parkinson's disease as it induced the synthesis of dopamine. A clinical trial of amantadine administration for three years showed that the incidence rate of pneumonia decreased to about 20% compared with the control group. Substance P is increased by angiotensin-converting enzyme inhibitors (ACE inhibitors). Conventional drugs can be used and are available by prescription. The use of such drugs separately or in combination enables prevention of pneumonia to a considerable degree.
期刊论文(36)
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Interventions to Prevento Pneumonia Among Older Adults
预防老年人肺炎的干预措施
DOI: --
发表时间: 2001
期刊: JAGS 49
影响因子: --
作者: [M.Yamaya, M.Yanai, T.Ohrui, H.Arai, H.Sasaki.]
通讯作者: H.Sasaki.
Risk factor of aspiration pneumonia in Alzheimer's disease patients.
阿尔茨海默病患者吸入性肺炎的危险因素。
DOI: --
发表时间: 2001
期刊: Gerontology 47
影响因子: --
作者: [H.Wada, K.Nakajoh, T.Satoh-Nakagawa, T.Suzuki, T.Ohrui, H.Arai, H.Sasaki.]
通讯作者: H.Sasaki.
K.Nakayama, Y.X.Jia, H.Hrai, M.Shinkawa, M.Yamaya, K.Sekizawa, H.Sasaki: "Acid stimulation reduces bactericidal activity of surface liquid in cultured human airway epithelial cells"Am. J. Respir. Cell. Mol. Biol.. 26. 105-113 (2002)
K.Nakayama、Y.X.Jia、H.Hrai、M.Shinkawa、M.Yamaya、K.Sekizawa、H.Sasaki:“酸刺激可降低培养的人呼吸道上皮细胞表面液体的杀菌活性”Am。
DOI: --
发表时间:
期刊:
影响因子: --
作者: []
通讯作者:
H.Sasaki, M.Yamaya, T.Ohrui, H.Kubo, S.Ebihara, H.Arai: "Characteristics of respiratory diseases in older people"JMAJ. 45(6). 231-236 (2002)
H.Sasaki、M.Yamaya、T.Ohrui、H.Kubo、S.Ebihara、H.Arai:“老年人呼吸系统疾病的特征”JMAJ。
DOI: --
发表时间:
期刊:
影响因子: --
作者: []
通讯作者:
36
    Survival period after tube feeding in bedridden older patient
    • 批准号:
      18590659
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.32万
    • 财政年份:
      2006
    • 负责人:
      SASAKI Hidetada
    • 依托单位:
    Interventions to prevent pneumonia among older adults
    • 批准号:
      10307014
    • 项目类别:
      Grant-in-Aid for Scientific Research (A).
    • 资助金额:
      $13.44万
    • 财政年份:
      1998
    • 负责人:
      SASAKI Hidetada
    • 依托单位:
    Protection of silent aspiration in the elderly
    • 批准号:
      07838002
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $1.47万
    • 财政年份:
      1995
    • 负责人:
      SASAKI Hidetada
    • 依托单位:
    Monitor system of cough and wheeging in bronchial asthma.
    • 批准号:
      04557036
    • 项目类别:
      Grant-in-Aid for Developmental Scientific Research (B)
    • 资助金额:
      $3.33万
    • 财政年份:
      1992
    • 负责人:
      SASAKI Hidetada
    • 依托单位:
    海外基金