Induction of drug induced tolerance in mice and application for large animals

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From analysis performed in 1995, the following results were obtained. 1) Chimerism was induced only in lymphocytes, and wasn't induced in bone marrow level. 2) In the combination of B10D2 and B10 (MHC alone disparate), clonal destruction was observed, but the induction of chimerism was transient, and 3) skin graft survival prolongation and duration of chimeric state had significnat relationship.From 1996, we started the analysis of our new protochol (SC+CP+Busulfan+Bone marrow cells protochol) to break through the MHC obstacle. We got very encouraging data that permanent chimerism and skingraft survaival were observed by using busulfan with our traditional CP induced tolorance protochol.The final goal that we want to achive is to induce tolerance only by drugs in large animals. And we think our new data is going to be a greater success.