Experimental organ transplantation: Application of the drug-induced immune tolerance-

环磷酰胺（CP）诱导的耐受性是一种基于混合嵌合的耐受性诱导方案。最近，我们报道了不变性自然杀伤T （iNKT）细胞在该系统的耐受性诱导中是必不可少的。在这项研究中，我们评估了iNKT细胞产生的细胞因子的作用。嵌合诱导的初始阶段需要iNKT细胞。我们的研究结果表明，已知的iNKT细胞产生的主要细胞因子对于iNKT细胞的调节功能是必不可少的。

Cyclophosphamide (CP)-induced tolerance is a mixed chimerism-based tolerance induction protocol. Recently, we reported that invariant natural killer T (iNKT) cells were essential for the tolerance induction in this system. In this study, we evaluated the roles of the cytokines produced by iNKT cells.iNKT cells were required in the initial phase of the induction of chimerism. Our results indicated that known major cytokines produced by iNKT cells were dispensable for the regulatory function of iNKT cells.