ARTIFICIAL NUCLEUS PULPOSUS FOR DEGENERATIVE LUMBAR SPINE

人工髓核治疗退变性腰椎

• 批准号: 07671573
• 负责人: OKAWA Atsushi
• 金额: $ 1.34万
• 依托单位: TOKYO MEDICAL AND DENTAL UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07671573/
• 关键词: LUMBAR SPINE; DEGENERATION; INSTABILTY; INTRADISCAL PRESSURE; BIOMECHANICS; ARTIFICIAL DISC; 変性腰椎; 腰椎不安定性; バイオメカニクス

The altered stiffness of the degenerated intervertebral disc (IVD) would affect a motion of the whole lumbar spine and be a cause of low back problems. An artificial intervertebral disc, being developed these days, will solve this problem, but the required surgery is as invasive as anterior interbody fusion operation. A substitute for nucleus pulposus can be an alternative treatment of degenerative lumbar disease. To obtain a basic information of the mechanical status of the degenerative lumbar spine, in this study, we examined the motion pattern of the whole lumbar spine using videofluoroscopy and measured intradiscal pressure during bending motion to know how much force is applied to the intervertebral disc in an actual motion.Lumbar sagittal motion videos were recorded under a fluoroscope in volunteers (n=14 ; age 22.4) and patients with CLBP (n=13 ; age 46.3) and degenerative spondylolisthesis (n=8 ; age 63.5), while the subjects bent forward from a standing neutral position and th … More en returned to the original position. The videos were converted to still images at 5 frames per second. Disk angles from L2-3 to L5-S1 were measured to estimate sagittal rotation. Disk degeneration was evaluated on T2 mid-sagittal MR image.In the control group (volunteers), 9 exhibited sequentially spreading motion, one exhibited simultaneous motion, and 3 showed confused starting points. the anterior bending motion is usually spread from the upper segment to the lower one, but six of the patients with degenerative spondylolisthesis showed disordered patterns. Decreased motion, persistent flexion, and earlier extension in a certain segment were more frequently seen in the patients than in controls. The decreased stiffness of one segment would affect the segmental motion pattern, resulting in the altered motion pattern of the whole lumbar spine.Before measuring the actual motion and the simulataneous change of the intradiscal pressure, we studied a validity of a transducer catheter. Five humane L3-L4 spinal unit obtained at autopsy was used. The intradiscal pressures did not change statistically at any site (anterior, posterior, lateral portion of the IVD) where the tip of the catheter was located. The pressure measured did not also change according to the direction of the tip of the catheter.In vivo we measured the intradiscal pressure in three segments to be fused at an operation. The subject moved from the neutral standing position, bending forward, and bent backward cyclically. The pressure on standing was 600-1000mmHg. Just after beginning to bend forward, the pressure raised steeply up to 2000mmHg, while the angular motion was only 0.6 degrees. This increased pressure was thought to be from paravertebral muscle contraction. When the subject continued to bend backward, the intradiscal pressure got lower around the neutral position than that of the beginning.Hydrogel is thought to be a ideal type of a high density polymer for a substitute of nucleus pulposus. However, materials with strong mechanical property did not exist as a hydrogel, and should be developed newly. This needs further advanced research. Less

退变的椎间盘（IVD）的刚度改变会影响整个腰椎的运动，并成为下背部问题的原因。目前正在开发的人工椎间盘将解决这个问题，但所需的手术与前路椎间融合术一样具有侵入性。髓核替代物可作为退行性腰椎疾病的替代治疗方法。为了获得退变腰椎力学状态的基本信息，在本研究中，我们使用视频透视检查整个腰椎的运动模式，并测量弯曲运动过程中椎间盘内的压力，以了解在实际运动中施加到椎间盘上的力的大小，在荧光镜下记录志愿者腰椎矢状面运动视频（n=14 ;年龄22.4）和CLBP（n=13 ;年龄46.3）和退行性脊椎滑脱（n=8 ;年龄63.5）患者，而受试者从站立中立位向前弯曲， ...更多信息 然后回到原来的位置。视频以每秒5帧的速度转换为静止图像。测量从L2-3到L5-S1的椎间盘角度以估计矢状旋转。在T2正中矢状位MRI图像上评估椎间盘退变，在对照组（志愿者）中，9个表现为顺序扩散运动，1个表现为同时运动，3个表现为混淆的起始点。前屈运动通常由上段向下段扩展，但6例退变性腰椎滑脱患者表现为紊乱型。与对照组相比，患者的运动减少、持续屈曲和某一节段的早期伸展更常见。一个节段刚度的降低会影响到整个节段的运动模式，从而导致整个腰椎的运动模式改变，在测量实际运动和椎间盘内压力的同步变化之前，我们研究了传感器导管的有效性。使用尸检时获得的5个人道L3-L4脊柱单元。在导管头端所在的任何部位（IVD的前部、后部、外侧部分），椎间盘内压力均无统计学变化。在体内，我们测量了在手术中融合的三个节段的椎间盘内压力。受试者从中立的站立位置移动，向前弯曲，并周期性地向后弯曲。站立位压力为600- 1000 mmHg。刚开始向前弯曲后，压力急剧上升至2000 mmHg，而角运动仅为0.6度。这种压力增加被认为是椎旁肌肉收缩引起的。当受试者继续向后弯曲时，中立位附近的椎间盘内压比开始时降低。水凝胶被认为是一种理想的高密度聚合物髓核替代物。然而，具有强机械性能的材料不存在作为水凝胶，并且应该开发新的。这需要进一步的深入研究。少