Electrically Induced Auditory Brainstem Response as a Clinical Tool in Explicating Sudden Deafness

电诱导听觉脑干反应作为解释突发性耳聋的临床工具

• 批准号: 07671869
• 负责人: USHISAKO Yasuaki
• 金额: $ 1.22万
• 依托单位: Miyazaki Medical College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07671869/
• 关键词: EABR; sudden deafness; Feosemide; stria vascularis; EP依存性難聴; モルモット

(1)Auditory brainstem responses to electrical stimulation (EABR) could be easily obtained by using bipolar electrodes in cochlear of guinea pig.(2)EABR to 500muA electrical stimulation in normal guinea pig showed five different positive peaks, but EABR wave forms were much different in each other than ABR wave forms.(3)Each peak latencies of EABR to 500muA were shortened about 1msec. compairing from its of ABR.(4)The mean EABR threshhold in normal guinea pigs was 55muA,ranging from 20muA to 100muA.(5)Cochlear damages caused by inserting electrodes for EABR recording introduced 8dB ascending in ABR threshhold.(6)Any latencies and thresholds in our EABR recordings were not infruenced by administrating 100mg/kg Frosemide.(7)Any latencies and thresholds in our EABR recordings were not infruenced by administrating 40mg/kg Kanamicine for 14 days.

（1）在豚鼠耳蜗内用双极电极可方便地获得电刺激听觉脑干反应（EABR）。（2）正常豚鼠对500 μ A电刺激的EABR出现5个不同的阳性峰，但EABR波形与ABR波形有较大差异。（3）EABR至500 μ A的各峰潜伏期缩短约1 msec。与其ABR相比，（4）正常豚鼠EABR阈值为55 μ A，范围为20 ~ 100 μ A。（5）插入电极引起的耳蜗损伤使ABR阈值升高8dB。（6）100 mg/kg剂量的Frosemide对EABR记录的潜伏期和阈值均无影响。（7）40 mg/kg卡那霉素连续给药14天，对EABR记录的潜伏期和阈值均无影响。