Cochlear blood flow in sudden deafness

突发性耳聋的耳蜗血流

• 批准号: 05671424
• 负责人: NAKASHIMA Tsutomu
• 金额: $ 1.02万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05671424/
• 关键词: Cochlear blood flow; Sudden deafness; Perilymphatic fistula; Laser Doppler flowmetry; Carbon dioxide; 二酸化炭素; レーザードップラー

Impairment of cochlear blood flow may be one of the factors implicated in the pathophysiology of sudden deafness. Cochlear blood flow in sudden deafness was measured in nine patients who were suspected of having perilymphatic fistulas. During exploratory tympanotomy, the tip of a laser-Doppler probe was attached to the promontory near the anterior portion of the round window niche. The distance between the exciting and receiving optic fibers was increased to elevate the maximum depth sensitivity. In all nine patients, pulsatory movement of the laser output that corresponded to ECG was observed. We attempted to measure effects of carbon dioxide on cochlear blood flow, such as inhalation of carbogen and cessation of respiration. In almost cases, however, no significant change of cochlear blood flow was observed by these procedures.

耳蜗血流障碍可能是导致突发性耳聋的病理生理因素之一。对9例怀疑有淋巴周围瘘管的突发性耳聋患者进行了耳蜗血流量测定。在探索性鼓室切开术中，激光多普勒探头的尖端附着在圆窗壁龛前部附近的海角上。为了提高最大深度灵敏度，增加了激发和接收光纤之间的距离。在所有9例患者中，观察到与ECG相对应的激光输出的脉动运动。我们试图测量二氧化碳对耳蜗血流的影响，如吸入碳和呼吸停止。然而，在大多数情况下，这些手术没有观察到耳蜗血流的显著变化。

项目成果

Nakashima T,Yanagita N et al.: "Comparative study on sudden deafness by two nationwide epidemiological surveys in Japan." Acta Otolaryngolo (Stockh). Suppl.514. 14-16 (1994)

Nakashima T、Yanagita N 等：“日本两次全国流行病学调查对突发性耳聋的比较研究”。

Nakashima T er al.: "Effects of vasodilating agents on cochlear blood flow in mice." Hearing research. 80. 241-246 (1994)

Nakashima T er al.：“血管舒张剂对小鼠耳蜗血流的影响。”

Nakashima T,Yanagita N: "Outcome of sudden deafness with and without vertigo." Laryngoscope. 103. 1145-1149 (1993)

Nakashima T、Yanagita N：“伴有或不伴有眩晕的突发性耳聋的结果。”

Nakashima T,Yanagita N et al.: "Comparative study on sudden deafness by two nationwide epidemiological surveys in Japan" Acta Otolaryngol (Stockh). Suppl 514. 14-16 (1994)

Nakashima T、Yanagita N 等：“日本两次全国流行病学调查对突发性耳聋的比较研究”Acta Otolaryngol (Stockh)。

中島務: "外リンパ瘻" 耳鼻臨床. 87. 1608-1609 (1994)

Tsutomu Nakajima：“外淋巴瘘”耳鼻喉科 87. 1608-1609 (1994)。