Physiological Investigation of the Laryngeal Protective Reflex Mechanism.

喉保护反射机制的生理学研究。

• 批准号: 07671866
• 负责人: TAKEMOTO Shin
• 金额: $ 1.54万
• 依托单位: Saga Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07671866/
• 关键词: mechanosensitive fibers; nucleus tractus solitarius; laryngeal mucosa; chemosensitive fibers; superior laryngeal nerve; 喉頭防御反射; 嚥下; 延髄両側神経回路; 孤東核; 嚥下関連ニューロン

To clarify the convergence of laryngeal afferents within the nucleus tractus solitarius (NTS) in the cat, we examined in the medulla the response characteristics of superior laryngeal nerve (SLN) fibers and NTS neurons to mechanical and chemical stimulation applied to laryngeal mucosa by extracellular recordings. The response was recorded in 75 SLN primary afferent fibers (PAFs) and 92 NTS neurons. PAFs of the SLN consisted of numerous monomodal mechanosensitive fibers and a small number of chemosensitive and polymodal fibers. On the other hand, the majority of NTS neurons had a polymodal nature. Thus, laryngeal information is considered to be integrated in modelity into NTS neurons. All mechanosensitive fibers received information from a small restricted field in the larynx. On the contrary, each NTS neuron responded to mechanical stimulation over a wide laryngeal field, indicating that information from different sited spatially converge on NTS neurons. Our results suggest that caudal NTS neurons play a cardinal role in integrating laryngeal afferents, which are thought to elicit laryngeal reflexes.

为了阐明喉传入神经在猫孤束核（NTS）内的会聚，我们用细胞外记录法研究了延髓上级喉神经（SLN）纤维和NTS神经元对机械和化学刺激作用于喉粘膜的反应特征。在75个SLN初级传入纤维（PAF）和92个NTS神经元中记录到这种反应。SLN的PAF由大量的单模态力学敏感纤维和少量的化学敏感和多模态纤维组成。另一方面，大多数NTS神经元具有多模态性质。因此，喉的信息被认为是集成到NTS神经元的模态。所有机械敏感纤维接收信息从一个小的限制领域在喉。相反，每个NTS神经元在一个宽的喉场对机械刺激作出反应，表明来自不同部位的信息在空间上会聚到NTS神经元。我们的研究结果表明，尾侧NTS神经元在整合喉传入，这被认为是引起喉反射发挥了至关重要的作用。

项目成果

Yu Y C,et al: "Neuroendocrine cells in the cat larygeal epithelium." Eur Arch Otorhinolaryngol.287-293 (1996)Vol 253.

Yu Y C,et al:“猫喉上皮中的神经内分泌细胞。”

宮崎純二: "ネコ迷走神経咽頭枝求心線維の起源と末梢および中枢の分布について" 耳鼻と臨床. 42. 1-9 (1996)

Junji Miyazaki：“猫迷走神经咽支传入纤维的起源和外周及中枢分布”《耳鼻喉科与临床研究》42. 1-9 (1996)。

Yu Y C,et al: "Neuroendocrine cells in the cat larygeal epithelium." Eur Arch Otorhinolaryngol.287-293 (1996)

Yu Y C,et al:“猫喉上皮中的神经内分泌细胞。”

梅崎俊郎 他: "神経機序からみた嚥下障害の診断と治療" JOHNS. 12. 588-589 (1996)

Toshiro Umezaki 等：“从神经机制的角度诊断和治疗吞咽困难”JOHNS. 12. 588-589 (1996)

Takemoto Shin, et al.: "Morphologic study of the laryngeal taste in the cat." Laryngoscope. Vol 105. 1315-1321 (1995)

Takemoto Shin 等人：“猫喉部味觉的形态学研究。”