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Detection of Early Normal-Tension Glaucoma without Visual Field Defects

无视野缺损的早期正常眼压青光眼的检测

基本信息

批准号：
07671909
负责人：
TOMITA Goji
金额：
$ 1.47万
依托单位：
Gifu University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1995
资助国家：
日本
起止时间：
1995 至 1997
项目状态：
已结题

项目摘要

In this project, four types of laser scanning ophthalmoscopes were evaluated with regard to their usefulness in assessing abnormalities of the optic nerve head due to glaucoma. The scanning laser tomograph had the advantage of enabling the examiner to evaluate the three-dimensional appearance of the optic nerve head and to detect abnormalities in the nerve fiber layr along the disc margin. Detailed assessment of nerve fiber layr defects in the macular region was possible using the laser scanning ophthalmoscope with an argon-blue laser. The scanning laser polarimeter allows the examiner to estimate the size of nerve fiber layr defects from the thickness of the nerve fiber layr as shown on the topographic map of the eye. Finally, use of the scanning laser Doppler flowmeter to examine eyes with advanced visual field defects showed that blood flow to the optic nerve head may be decreased with advanced visual field defects showed that blood flow to the optic nerve head may be decreased in t … More hese eyes. These results indicated that to use these scanning laser devices is useful to early detection of glaucoma as well as visual field testing.In addition to using optic disc parameters and retinal nerve fiber layr findings for diagnosing early glaucoma, to identify presence of peripapillary atrophy or splinter hemorrhage has been revealed to be another important landmarks. On the other hand, in normal-tension glaucoma patients with only superior or inferior hemifield dominant defects, the relation between visual field indices, obtained by automated perimetry, and optic disc parameters determined via confocal laser scanning tomography and retinal nerve fiber layr thickness determined via scanning laser polarimetry was assessed. We found that even in the optic tic parameters or nerve fiber layr thickness corresponding to the unaffected hemifield, there were statistically, significant worsening in these parameters. It was concluded that the optic nerve head or nerve fiber layr abnormalities may be detectable in areas of apparently normal visual field in normal-tension glaucoma. Less

在这个项目中，四种类型的激光扫描检眼镜进行了评估，其在评估视神经乳头异常青光眼的有用性。激光断层扫描的优点是检查者能够评价视神经乳头的三维外观，并发现沿着椎间盘边缘的神经纤维层异常。使用氩蓝激光的激光扫描检眼镜可以详细评估黄斑区的神经纤维层缺陷。扫描激光偏振仪允许检查者根据眼睛的地形图上所示的神经纤维层的厚度来估计神经纤维层缺损的大小。最后，使用扫描激光多普勒血流计检查晚期视野缺损的眼睛，发现晚期视野缺损的视神经头血流可能减少，表明晚期视野缺损的视神经头血流可能减少。 ...更多信息他的眼睛。这些结果表明，使用这些激光扫描装置有助于青光眼的早期发现和视野检查，除了使用视盘参数和视网膜神经纤维层检查来诊断早期青光眼外，识别视乳头周围萎缩或碎片出血也是另一个重要标志。另一方面，在只有上级或低级半视野优势缺陷的正常眼压性青光眼患者中，通过自动视野计获得的视野指数与通过共聚焦激光扫描断层扫描确定的视盘参数和通过扫描激光偏振仪确定的视网膜神经纤维层厚度之间的关系进行了评估。我们发现，即使在对应于未受影响的半野的视神经抽动参数或神经纤维层厚度中，这些参数也有统计学上的显著恶化。结论：正常眼压性青光眼视神经乳头或神经纤维层的异常可在正常视野的区域检测到。少