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Experimental and clinical investigation on visual dysfunction in eyes with ischemic retinochoroidal disorders

缺血性视网膜脉络膜疾病眼视功能障碍的实验与临床研究

基本信息

批准号：
07671907
负责人：
IIJIMA Hiroyuki
金额：
$ 0.96万
依托单位：
Yamanashi Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1995
资助国家：
日本
起止时间：
1995 至 1996
项目状态：
已结题

项目摘要

Clincally the branch retinal artery occlusion was mainly investigated. The field defect showed either absolute scotoma or sensitivity loss by 20 dB or larger. A large difference between sensitivities in each pair of upper and lower measured points adjacent to the horizontal line nasal to Mariott's scotoma, which indicated a straight border between the defective field and the normal area. The patients with branch retinal artery occlusion showed high incidence of heart diseases or internal carotid artery disease that might cause embolism. Retinal emboli were often observed in these patients. The location of emboli did not always corresponded to the site of occlusion. In patients with age related macular degeneration with choroidal neovascularization many eyes needed second laser therapy due to persistent or recurrent choroidal neovascularization that was detected with fluorescein angiogram taken 6 weeks or less after the initial laser therapy, which suggests the need of careful follow-up with periodical fluorescein angiogram in the management of this disease. 13EA02 : Experimental photodynamic thrombosis was created by intravenous rose bengal injection followed by irradiation with a light source of surgical microscope in the retinal and choroidal vessels of rat and rabbit eyes. Vessel obliteration was observed using video fluorescein angiography with scanning ophthalmoscopy. Photopic electroretinogram showed amplitude reduction and delay in peak latency.

临床主要研究视网膜分支动脉闭塞。磁场缺陷表现为绝对暗斑或灵敏度损失20 dB或更大。靠近马里奥氏暗点鼻部水平线的每对上下测点灵敏度差异较大，表明缺陷视场与正常区域之间存在直线边界。视网膜分支动脉闭塞患者的心脏病或颈内动脉疾病发生率高，可引起栓塞。在这些患者中经常观察到视网膜栓塞。栓子的位置并不总是与闭塞部位相对应。在年龄相关性黄斑变性伴脉络膜新生血管的患者中，由于初始激光治疗后6周或更短时间内荧光素血管造影检测到脉络膜新生血管的持续或复发，许多眼睛需要第二次激光治疗，这表明在治疗这种疾病时需要定期荧光素血管造影进行仔细的随访。13EA02：用手术显微镜光源照射大鼠和兔眼视网膜血管和脉络膜血管，经静脉注射孟加拉玫瑰形成实验性光动力血栓。扫描眼镜下视频荧光素血管造影观察血管闭塞。视网膜光电图表现为振幅降低和峰潜伏期延迟。