Experimental and clinical investigation on visual dysfunction in eyes with ischemic retinochoroidal disorders

临床上主要研究视网膜分支动脉阻塞。视野缺陷表现为绝对暗点或敏感度下降20分贝或以上。与Mariott‘s暗点相邻的水平线附近的每对上下测量点的敏感度差异很大，这表明缺损区和正常区之间有一条直线边界。视网膜分支动脉阻塞患者心脏疾病或颈内动脉疾病的发生率较高，可能导致血栓形成。视网膜栓子多见于这些患者。栓子的位置并不总是与闭塞的位置相对应。对于老年性黄斑变性伴脉络膜新生血管的患者，许多眼在初次激光治疗后6周或更短时间内通过荧光素血管造影检测到持续或复发的脉络膜新生血管而需要再次激光治疗，提示在这种疾病的治疗中需要定期进行荧光血管造影的仔细随访。13EA02：静脉注射孟加拉玫瑰，然后用手术显微镜光源照射大鼠和兔眼的视网膜和脉络膜血管，建立实验性光动力血栓形成模型。扫描眼底镜下视频荧光素血管造影观察血管闭塞情况。视网膜电信号表现为波幅降低，峰潜伏期延长。

Clincally the branch retinal artery occlusion was mainly investigated. The field defect showed either absolute scotoma or sensitivity loss by 20 dB or larger. A large difference between sensitivities in each pair of upper and lower measured points adjacent to the horizontal line nasal to Mariott's scotoma, which indicated a straight border between the defective field and the normal area. The patients with branch retinal artery occlusion showed high incidence of heart diseases or internal carotid artery disease that might cause embolism. Retinal emboli were often observed in these patients. The location of emboli did not always corresponded to the site of occlusion. In patients with age related macular degeneration with choroidal neovascularization many eyes needed second laser therapy due to persistent or recurrent choroidal neovascularization that was detected with fluorescein angiogram taken 6 weeks or less after the initial laser therapy, which suggests the need of careful follow-up with periodical fluorescein angiogram in the management of this disease. 13EA02 : Experimental photodynamic thrombosis was created by intravenous rose bengal injection followed by irradiation with a light source of surgical microscope in the retinal and choroidal vessels of rat and rabbit eyes. Vessel obliteration was observed using video fluorescein angiography with scanning ophthalmoscopy. Photopic electroretinogram showed amplitude reduction and delay in peak latency.