Application of antimicrobial monomers for acrylic denture resin.

合成了8种甲基丙烯酸酯单体，并将其作为抗菌剂应用于丙烯酸基托树脂材料中。这些抗菌单体与甲基丙烯酸甲酯(MMA)/甲基丙烯酸羟乙酯(HEMA)溶解，然后与聚甲基丙烯酸甲酯粒子聚合。通过测定白色念珠菌的贴壁细胞数来评价含有该单体的树脂的抗菌活性。合成的四种抗菌剂单体均表现出中等的抗菌活性。这些抗菌单体的加入不影响固化树脂的显微硬度。其中三种单体是季胺化甲基丙烯酸酯单体。尽管季胺化单体表现出中等的抗菌活性，但它们与MMA单体的溶解性相当低。因此，有限浓度的这些单体可以结合到义齿丙烯酸树脂中。其余5种单体均为非季铵盐化甲基丙烯酸酯单体，可在较高浓度下与甲基丙烯酸甲酯溶解。这些非季胺化单体的抗菌活性尚不清楚。本研究结果表明，将这些单体应用于丙烯酸酯义齿树脂中，可提高固化树脂的抗菌活性。

Eight kinds of methacrylate monomers were synthesized and applied to acrylic denture base resin material as antimicrobial ingredient.. These antimicrobial monomers were dissolved with methyl methacrylate (MMA) /hydroxyethyl methacrylate (HEMA), and polymerized with polymethylmethacrylate particles. The antimicrobial activity of the resin containing such monomer was evaluated by measuring the number of adhered cell of Candida albicans. Four types of antimicrobial monomers of synthesized monomers showed a moderate antimicrobial activity. The microhardness of the cured resins were not affected by incorporation of these antimicrobial monomers. Three of these monomers were quaternarized methacrylate monomers. Although the quaternarized monomers showed a moderate antimicrobial activity, their solubility with MMA monomer were considerably lower. Therefore, a limited concentration of these monomers could incorporate to denture acrylic resin. Other five monomers were nonquaternarized methacrylate monomers, and could dissolve with MMA with higer concentration. The antimicrobial activity for these nonquaternarized monomers were not known yet. The results of this study suggested that the application of these monomers to acrylic denture resin would increase antimicrobial activity of cured resin.