Application of antimicrobial monomers for acrylic denture resin.

抗菌单体在丙烯酸义齿树脂中的应用

• 批准号: 07672147
• 负责人: KAWAGUCHI Minoru
• 金额: $ 1.02万
• 依托单位: Fukuoka Dental College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07672147/
• 关键词: methacrylate; monomer; acrylic resin; denture; adhesion; bacteria; 義歯床用レジン; 抗菌性; プラーク

Eight kinds of methacrylate monomers were synthesized and applied to acrylic denture base resin material as antimicrobial ingredient.. These antimicrobial monomers were dissolved with methyl methacrylate (MMA) /hydroxyethyl methacrylate (HEMA), and polymerized with polymethylmethacrylate particles. The antimicrobial activity of the resin containing such monomer was evaluated by measuring the number of adhered cell of Candida albicans. Four types of antimicrobial monomers of synthesized monomers showed a moderate antimicrobial activity. The microhardness of the cured resins were not affected by incorporation of these antimicrobial monomers. Three of these monomers were quaternarized methacrylate monomers. Although the quaternarized monomers showed a moderate antimicrobial activity, their solubility with MMA monomer were considerably lower. Therefore, a limited concentration of these monomers could incorporate to denture acrylic resin. Other five monomers were nonquaternarized methacrylate monomers, and could dissolve with MMA with higer concentration. The antimicrobial activity for these nonquaternarized monomers were not known yet. The results of this study suggested that the application of these monomers to acrylic denture resin would increase antimicrobial activity of cured resin.

合成了8种甲基丙烯酸酯单体，并将其作为抗菌成分应用于丙烯酸义齿基托树脂材料。这些抗菌单体与甲基丙烯酸甲酯(MMA) /甲基丙烯酸羟乙酯（HEMA）溶解，并与聚甲基丙烯酸甲酯颗粒聚合。通过对白色念珠菌粘附细胞数的测定，评价了含该单体树脂的抗菌活性。合成的4种抗菌单体均表现出中等的抗菌活性。这些抗菌单体的掺入不影响固化树脂的显微硬度。其中三个单体是甲基丙烯酸酯季铵化单体。虽然季铵化单体表现出中等的抗菌活性，但它们与MMA单体的溶解度明显较低。因此，这些单体的浓度有限，可以纳入义齿丙烯酸树脂。其余5个单体均为非季铵化的甲基丙烯酸酯单体，可与MMA以较高的浓度溶解。这些非季铵化单体的抗菌活性尚不清楚。本研究结果表明，将这些单体应用于丙烯酸义齿树脂中可以提高固化树脂的抗菌活性。

项目成果

川口稔: "抗菌性モノマーの義歯床用レジンへの応用" 歯科材料・器械. 15巻、528. 282-283 (1996)

Minoru Kawaguchi：“抗菌单体在义齿基托树脂中的应用”《牙科材料和仪器》第 15 卷，528. 282-283 (1996)。