Determination of concentration level for antmicrobial heterocyclic metahcrylate monomers for dental use

牙科用抗菌杂环甲基丙烯酸酯单体浓度水平的测定

• 批准号: 10671857
• 负责人: KAWAGUCHI Minoru
• 金额: $ 1.54万
• 依托单位: Fukuoka Dental College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10671857/
• 关键词: methacrylate; monomer; denture base; relining; antimicrobial activity; アクリルレジン; 抗菌性モノマー; アクリルモノマー; リライニング材; 裏装

The six kinds of heterocyckic methacrylate monomers were prepared and investigated their antimicrobial activity to Candida albicans. Denture base acrylic resins containing these monomers were subjected to phosphate buffer solution containing C. albicans. The antimicrobial activity of these resins was evaluated from counting the accumulated cells on the resin surface. The results indicated that these heterocyclic monomers, especially imidazole methacrylates, have good antimicrobial activity. Furthermore, we prepared the direct reline materials containing the imidazole methacrylate monomers to apply the denture relining. The results for the reline materials showed same tendency to those for denture base acrylic resins. These results suggested that the imidazole methacrylate monomers would have good potential of antimicrobial activity and be useful to various denture base and reline materials.

制备了6种甲基丙烯酸杂环酯单体，考察了它们对白色念珠菌的抑菌活性。含有这些单体的义齿基丙烯酸树脂被置于含有白色念珠菌的磷酸盐缓冲溶液中。通过计算树脂表面积累的细胞数来评价树脂的抗菌活性。结果表明，这些杂环单体，特别是咪唑类甲基丙烯酸酯具有良好的抗菌活性。在此基础上，制备了含甲基丙烯酸咪唑单体的直接衬线材料用于义齿衬层。义齿基托丙烯酸树脂与牙线材料的结果相同。这些结果表明，甲基丙烯酸咪唑单体具有良好的抗菌活性，可用于各种义齿基托和衬线材料。

项目成果

川口 稔、高橋 裕 宮崎光治、羽生哲也: "化学重合型直接リライニング材からの残留モノマーの溶出性" 歯科材料・器械. 17巻5号. 304-308 (1998)

Minoru Kawaguchi、Yutaka Takahashi、Mitsuharu Miyazaki、Tetsuya Hanyu：“化学聚合直接衬里材料中残留单体的洗脱”《牙科材料和仪器》第 17 卷，第 5 期。304-308 (1998)。