Determination of concentration level for antmicrobial heterocyclic metahcrylate monomers for dental use

合成了六种杂环甲基丙烯酸酯单体，并研究了它们对白色念珠菌的抑菌活性。将含有这些单体的义齿基丙烯酸树脂置于含有白色念珠菌的磷酸盐缓冲液中。通过计数树脂表面积累的细胞数来评价这些树脂的抗菌活性。结果表明，这些杂环单体，特别是咪唑甲基丙烯酸酯具有良好的抗菌活性。此外，我们还制备了用于义齿修复的含咪唑甲基丙烯酸酯单体的直接修复材料。修复体材料的结果与义齿基托丙烯酸树脂的结果相同。这些结果表明，咪唑甲基丙烯酸酯单体具有良好的抗菌活性，可用于各种义齿基托和修复材料。

The six kinds of heterocyckic methacrylate monomers were prepared and investigated their antimicrobial activity to Candida albicans. Denture base acrylic resins containing these monomers were subjected to phosphate buffer solution containing C. albicans. The antimicrobial activity of these resins was evaluated from counting the accumulated cells on the resin surface. The results indicated that these heterocyclic monomers, especially imidazole methacrylates, have good antimicrobial activity. Furthermore, we prepared the direct reline materials containing the imidazole methacrylate monomers to apply the denture relining. The results for the reline materials showed same tendency to those for denture base acrylic resins. These results suggested that the imidazole methacrylate monomers would have good potential of antimicrobial activity and be useful to various denture base and reline materials.