Cell adhesion of various ceramics

各种陶瓷的细胞粘附

• 批准号: 07672141
• 负责人: TAKEDA Shoji
• 金额: $ 1.15万
• 依托单位: Osaka Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07672141/
• 关键词: ceramics; cell adhesion; shear stress; dynamic contact angle; oxidation; セラミックス; 血清

We investigated the cell adhesion rate of various engineering ceramics such as Al_2O_3, ZrO_2, Si_3N_4, TiN,and TiC by measuring the relative cell adhesion rate as assessed by a cell count and image analyzer. Titanium and titanium alloy that were oxidized by heating, were also examined by measuring the dynamic contact angle and the percent of adherent cells. Five kinds of engineering ceramics showed a cell adhesion as good as did plastic petri dishes. On the other hand, the surface modification of titanium and titanium alloys decreased the contact angle, but had only a small influence on the percentage of adherent cells. The percentage of adherent cells decreased in every condition with a longer application of shear stress.The results suggest that engineering ceramics may be of use as biomaterials. In addition, evaluation of the surface modification may be useful to examine aspects of the material surface.

用细胞计数和图像分析仪测定了Al_2O_3、ZrO_2、Si_3N_4、TiN和TiC等工程陶瓷的相对细胞粘附率。通过动态接触角和贴壁细胞百分率的测定，研究了钛及钛合金在高温氧化条件下的力学性能。5种工程陶瓷的细胞粘附性与塑料培养皿相当。钛及钛合金的表面改性降低了接触角，但对贴壁细胞百分率影响不大。随着剪切力作用时间的延长，贴壁细胞的百分率逐渐降低，说明工程陶瓷有可能作为生物材料使用。此外，对表面改性的评估可能有助于检查材料表面的各个方面。

项目成果

河出 任弘, 武田 昭二: "チタンおよびチタン合金の細胞接着に対するずり応力の影響" 歯科材料・器械. 15. 161-168 (1996)

Toshihiro Kawade、Shoji Takeda：“剪切应力对钛和钛合金细胞粘附的影响”牙科材料和仪器 15. 161-168 (1996)。