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DEVELOPMENT OF ANTIMICROBIAL DENTAL RESIN MATERIALS

抗菌牙科树脂材料的开发

基本信息

批准号：
07672132
负责人：
KURATA Shigeaki
金额：
$ 1.54万
依托单位：
KANAGAWA DENTEL COLLEGE
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1995
资助国家：
日本
起止时间：
1995 至 1996
项目状态：
已结题

项目摘要

Polymeric phosphonium salt was studied to develop antimicrobial dental resin. Phosphonium salt monomer was tributyl (4-vinylbenzyl)-phosphonium chloride (V), and acrylic acid (A) and methacryloyloxyethyl-trimethylammonium chloride (M) were used as control. Antimicrobial activity of those monomers and the corresponding polymers (PA,PM,PV) to Streptococcus mutans Ingbritt were examined. The degree of antimicrobial activity of A,PA and PM was lessthat of PM and V were some little, and that or PV was good.The V or M was dissolved in the mixed monomer of methyl methacrylate and 2-hydroxyethyl methacrylate at 8 : 2 molar ratio The monomer mixtures were cured with benzoyl peroxide in a glass tube. The content of V and M in the copolymer was 1,2 and 3mole% for V and 1mole% for M (The abbreviation of the copolymers : CV1, CV2, CV3 and CM1, respectively, and that of the copolymer without V and M : C). The cured copolymers with dimensions of 10mm in diameter and 1mm in thickness were immersed in a medium containing Streptococcus mutans Ingbritt and incubated anaerobically for 24hours at 37ﾟC.The amount of accumulated bacteria on the copolymer was determined with an optical densitometer. The amount of adhered bacteria on CV1, CV2 and CV3 was significantly less than those of C and M.The compressive and bending strengths of those copolymers decreased with a increase of the monomer in the copolymer, for example, the compressive and bending strength fo CV1 and CM1 were about 10% and 20% less, respectively, than those of C.

研究了高分子磷盐在牙科抗菌树脂中的应用。鏻盐单体为三丁基（4-乙烯基苄基）-氯化鏻（V），丙烯酸（A）和甲基丙烯酰氧基乙基-三甲基氯化铵（M）用作对照。研究了这些单体及其聚合物（PA、PM、PV）对变形链球菌Ingbritt的抗菌活性。A、PA和PM的抑菌效果较好，PM和V的抑菌效果稍差，PV的抑菌效果较好。将V或M溶于摩尔比为8：2的甲基丙烯酸甲酯和甲基丙烯酸2-羟乙酯的混合单体中，在玻璃试管中与过氧化苯甲酰进行固化。共聚物中V和M的含量分别为1、2和3mol%V和1mol%M（简称CV 1、CV 2、CV 3和CM 1，不含V和M的共聚物简称：C）。将直径为10 mm、厚度为1 mm的固化共聚物浸入含有变形链球菌Ingbritt的培养基中，并在37 ℃厌氧培养24小时。随着共聚物中单体含量的增加，共聚物的抗压强度和弯曲强度均下降，其中CV1和CM 1的抗压强度和弯曲强度分别比C的低10%和20%左右。