Study on Development of Antibacterial Dental Resin using Silver Methacrylate as an Antibacterial Substance

以甲基丙烯酸银为抗菌物质的抗菌牙科树脂的开发研究

• 批准号: 15592079
• 负责人: KURATA Shigeaki
• 金额: $ 1.66万
• 依托单位: Kanagawa Dental College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15592079/
• 关键词: Antibacterial activity; dental resin; Silver methacrylate; Silver ion

There is the research of dental resin which made silver ion to be antibacterial substance until now. The silver ion is fixed to the carrier such as zeolite, the carrier is mixed with the resin, and the composite resin is made. The silver ion has not uniformly been dispersed in composite material, and in addition the toughness of the composite resin decrease.The development of antibacterial dental resin using silver meyhacrylate monomer (MAg) as an antibacterial substance was tried. The solubility of MAg in methyl methacrylate (MMA) was examined, and then the mechanical property of the polymer obtained by polymerization of MAg-containing MMA was tested. As a results, MAg was dissolved to MMA in a concentration of 84×10^<-6> mol/l (about 9 ppm). And it was suggested that the concentration was enough for the appearance of antibacterial activity, because the smallest extinction concentration of silver ion for a Escherichia coil is 3〜13ppm. The Compressive and bending strength of the copolymer of MMA and 2-Methacryloyloxyethyltrimethyl ammonium chloride (MC) decreased with the content of MC. However MAg-containing resin obtained was transparent colorlessness, and there was no problem in esthetics. The compressive and bending strength of the resin were not significantly different compared with those of PMMA The silver ions in the resin does not dissolve into water. MAg-containing resin can be expected as an antibacterial dental resin.

迄今为止，已有将银离子制成抗菌物质的牙科树脂的研究。将银离子固定在沸石等载体上，将载体与树脂混合，制成复合树脂。银离子在复合材料中分散不均匀，而且复合树脂的韧性下降。尝试了以甲基丙烯酸银单体(MAg)作为抗菌物质开发抗菌牙科树脂。考察了MAg在甲基丙烯酸甲酯(MMA)中的溶解度，然后测试了通过含MAg的MMA聚合得到的聚合物的机械性能。结果，MAg以84×10 6 -6 mol/l(约9ppm)的浓度溶解到MMA中。由于银离子对大肠杆菌的最小消光浓度为3〜13ppm，因此表明该浓度足以出现抗菌活性。 MMA与2-甲基丙烯酰氧基乙基三甲基氯化铵(MC)共聚物的压缩强度和弯曲强度随着MC含量的增加而降低。然而，获得的含MAg树脂是透明无色的，并且在美观上没有问题。该树脂的压缩强度和弯曲强度与PMMA相比没有显着差异。树脂中的银离子不溶于水。含MAg的树脂有望成为抗菌牙科树脂。

项目成果

メタクリル酸銀を応用した抗菌性歯科用レンジ材料(その3)

使用甲基丙烯酸银的抗菌牙科微波材料（第3部分）

• 发表时间: 2005
• 期刊: 神奈川歯科大学学会 第14回プログラム
• 作者: 田村隆典;深瀬康公;伊藤公一 他;倉田茂昭ほか
• 通讯作者: 倉田茂昭ほか

メタクリル酸銀を応用した抗菌性歯科用レンジ材料(第1報)

使用甲基丙烯酸银的抗菌牙科微波材料（第1次报告）

• 发表时间: 2005
• 期刊: 歯科材料・器械 24
• 作者: T.Tamura;Y.Fukase;K.Ito;倉田茂昭ほか
• 通讯作者: 倉田茂昭ほか

メタクリル酸銀を用いた歯科用レジンの抗菌性(その2)

使用甲基丙烯酸银的牙科树脂的抗菌性能（第 2 部分）

• 发表时间: 2004
• 期刊: 神奈川歯科大学学会 第39回総会プログラム
• 作者: 倉田茂昭ほか;倉田茂昭ほか
• 通讯作者: 倉田茂昭ほか

Study on the development of antibacterial dental resin using silver methacrylate as an antibacterial Part 1 Solubility of silver methacrylate in MMA and the mechanical strength of the resin with silver methacrylate

以甲基丙烯酸银为抗菌剂的抗菌牙科树脂的开发研究第1部分甲基丙烯酸银在MMA中的溶解度及含甲基丙烯酸银的树脂的机械强度

• 发表时间: 2005
• 期刊: The journal of the Japanese Society for Dental Materials and Devices Vol.24, No.6
• 作者: Shigeaki Kurata;Tomotaro Nihei;Kozo Umemoto
• 通讯作者: Kozo Umemoto

Study on the development of antibacterial dental resin using silver (Part 3)

银抗菌牙科树脂的开发研究（三）

• 发表时间: 2005
• 期刊: Kanagawa Dental College 40^<th> general meeting, Yokosuka, Kanagawa. Abstract book
• 作者: Shigeaki Kurata;Tomotaro Nihei;Kazuo Shimoyama;Kozo Umemoto
• 通讯作者: Kozo Umemoto