In-situ biofunctionalisation for additive manufacturing

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Additive manufacturing that incorporates printing of live cells can create hierarchical, multi-component structures that mimic biology. However, an ability to include spatially segregated biological cues is currently lacking. This project will develop plasma pen modules to selectively functionalise surfaces and interfaces, as they are being printed, with robustly immobilised hydrogels and biological signalling molecules to direct cell behaviour. The expected outcome is a green technology enabling the fabrication of structures that replicate the native environments of cells in the body to provide optimal efficacy in drug discovery and regenerative medicine, and significant benefits for the Australian biomedical sector.