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Role of growth factors and morphogens in cell differentiation

生长因子和形态发生素在细胞分化中的作用

基本信息

批准号：
08045066
负责人：
ARASE Seiji
金额：
$ 3.78万
依托单位：
The University of Tokushima, School of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for international Scientific Research
财政年份：
1996
资助国家：
日本
起止时间：
1996 至 1998
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08045066/
关键词：
dermal papilla specific genes dermal papilla Langerhans cells allogenic blood stem cells transplant gap junction tyrosine kinase atherosclerosis TGF-beta 糖尿病トランスゼニックマウス amylin activin 同種抹消血移植毛乳頭特異的遺伝子動脈粥状変成 gap junction

项目摘要

Project activity : In 1999, Cooper visited The University of Tokushima from Jan.4 to 10. He had a close meeting mainly with Prof Itakura on collaborative research works about the roles of amylin on the pathogenesis of diabetes mellitus and schizophrenia. He also gave a lecture to medical students and postgraduate students. Arase, Itakura and Kosaka visited The University of Gackland from March 16 to 20. gave seminors to postgraduate students, then had closing meetings of this research project with all members. Finally, we decided to exchange not only research informations but also students and postgraduate students between the corresponding departments.Researctr summary : Arase has found 8 human dermal papilla specific genes and now studing functions of them by developing knock-out animals. Itakura developed both beta cells related genes' transgenic and knockout animal's to precisely elucidate functions of those gene products. Kawano and Kosaka developed peripheral blood stem cells transplantation therapy from HLA mismatched donners. They treaLed both pediatric and adult patients with haeniatological malignancies using their methods. Merriless studied the relationship between the formation of atherosclerosis and proteoglycans and found TGF-beta enhances the proteoglycans production by endothelial cells. Green found an important role of gap junction in wound healing. Cooper found a close relation between arnylin and diabctes mellitus, schizophrenia. Crosiers found knew developiriental tyrosine kinase genes and fixed their full length DNA sequence. France and Kosaka studied the relationship between premature birthand maternal serum levels of CRH, activin-A and follistatin but found no association.

项目活动：1999年1月4日至10日，Cooper访问了日本德岛大学。他与Itakura教授就胰淀素在糖尿病和精神分裂症发病机制中的作用进行了密切的合作研究。他还为医科学生和研究生做过讲座。3月16日至20日，Arase、Itakura和Kosaka访问了新西兰大学。给研究生上了课，然后和所有成员开了这个研究项目的闭幕会。最后，我们决定不仅交换研究信息，还交换相应部门之间的学生和研究生。研究人员总结：Arase已经发现了8个人类真皮乳头特异性基因，目前正在通过开发敲除动物来研究它们的功能。Itakura开发了β细胞相关基因的转基因和敲除动物，以精确阐明这些基因产物的功能。Kawano和Kosaka开发了来自HLA错配供者的外周血干细胞移植疗法。他们用他们的方法治疗儿科和成人的血管病恶性肿瘤患者。Merriless研究了动脉粥样硬化的形成与蛋白聚糖之间的关系，发现tgf - β增强了内皮细胞蛋白聚糖的产生。Green发现了缝隙连接在伤口愈合中的重要作用。库伯发现龙葵素与糖尿病、精神分裂症有密切关系。Crosiers发现了已知的发育酪氨酸激酶基因，并固定了它们的全长DNA序列。France和Kosaka研究了早产与母体血清CRH、激活素a和卵泡抑素水平的关系，但没有发现关联。