Space, time and boundary conditions: Mathematics for evolving plaques.

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This project aims to create new mathematical theory to model the morphology of atherosclerotic plaques, which cause heart attacks and strokes, as plaques grow or regress. The project expects to devise new mathematical tools for formulating novel spatial models for cellular processes inside the plaque. These should give a new window into plaque growth and spatial structures . Expected outcomes include powerful and reliable mathematical models, new tools to understand plaque evolution, and national and international collaborations with scientists and mathematicians. This should provide significant benefits including increased capacity to use mathematical models in vascular biology and training young researchers in interdisciplinary methods.