Epigenetic effects of environmental thyroid disruption

环境甲状腺破坏的表观遗传效应

• 批准号: DP220101342
• 负责人: Prof Frank Seebacher
• 金额: $ 31.85万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-03-28 至 2025-03-27
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220101342
• 关键词: Epigenetic; effects; environmental; thyroid; disruption

Anthropogenic impacts increasingly disrupt hormone-mediated responses to environmental change. The project aims to determine the interactive effects of climate warming, light-at-night, and plastic pollution on thyroid hormone signalling, and test whether these effects are passed between generations epigenetically. Epigenetic effects of endocrine disruption are one of the most important emerging conservation threats. Mathematical modelling of experimental data will help to predict how animals respond to anthropogenic impacts, and to acquire the tools necessary to maintain ecosystem function and services. The project will therefore have environmental benefits, as well as social benefits stemming from international collaborations and training.

人为影响日益破坏激素介导的对环境变化的反应。该项目旨在确定气候变暖、夜间光线和塑料污染对甲状腺激素信号的相互影响，并测试这些影响是否会在代与代之间通过表观遗传传递。内分泌干扰的表观遗传效应是最重要的新兴保护威胁之一。实验数据的数学建模将有助于预测动物对人为影响的反应，并获得维持生态系统功能和服务所需的工具。因此，该项目将具有环境效益，以及来自国际合作和培训的社会效益。