Expression of new cell-cell adhesion molecule and mucin genes in cancers : its relationship with invasion or metastasis of cancers

1. (1)食管鳞状细胞癌（scc）细胞系与人内皮细胞系产生相同的血栓调节素（TM）分子。低表达tm的食管SCC细胞比高表达tm的食管SCC细胞具有更高的侵袭性。(2)在口腔和肺部SCCs中，淋巴结转移灶中TM阳性表达的肿瘤细胞明显少于原发肿瘤。(3)在咽、喉、食管鳞状细胞癌中，唾液化MUC1粘蛋白（DF3抗原）是有效的肿瘤标志物。DF3抗原唾液寡糖的表达与食管鳞状细胞癌预后不良有关。(1)即使在胰腺和肝内胆管的扩张性生长型肿瘤中，肿瘤的侵袭性生长区也具有侵袭性生长型肿瘤中常见的MUC1粘蛋白表达特征。(2)原位杂交研究发现，MUC2粘蛋白在胰腺和肝内胆管扩张型肿瘤中的表达受MUC2mRNA的调控。肿瘤中MUC2mRNA表达阳性的患者生存率明显高于肿瘤中MUC2mRNA表达阴性的患者。(3) MUC5AC（胃型）和MUC2（肠型）基因在侵袭性较小的“胰腺粘蛋白生成瘤”（mucin - proliferingtumors of pancreatic, MPTs）中的表达模式在不同亚型间存在差异。(4)在胰腺和肝内胆管肿瘤中，MUC1粘蛋白的唾液酸表位似乎在侵袭生长中起重要作用。(5)在壶腹癌和胃癌中，MUC1（+）表达患者预后差于MUC1（-）表达患者，而MUC2（+）表达患者预后好于MUC2（-）表达患者。(6)结直肠上皮性肿瘤中结膜周围成纤维细胞鞘的显著减少反映了腺瘤-癌序列的进展。少

1. Squamous cell carcinoma(1) Esophageal squamous cell carcinoma (S CC) cell lines produced the same thrombomodulin (TM) molecule as human endothelial cell line. The TM-low-expressing esophageal SCC cells expressed high invasiveness than TM-high-expressing esophageal SCC cells.(2) In SCCs of oral cavity and lung, the tumor cells that were positive for TM expression were significantly rarer in the lymph node metastatic lesions than in the primary tumors.(3) In SCCs of pharynx and larynx, and of esophagus, sialylated MUC1 mucin (DF3 antigen) was an effective tumor marker. The expression of sialyl oligosaccharides of DF3 antigen was related to poor prognosis in esophageal SCCs.2. Adenocarcinoma(1) Even in the expansive growth type tumors of pancreas and intrahepatic bile duct, invasive growth areas of the tumors acquire a characteristic of MUC1 mucin expression that is usually seen in the invasive growth type tumors.(2) In situ hybridization study disclosed that MUC2 mucin expression in m … More ost of expansive growth type tumors of pancreas and intrahepatic bile duct was regulated by MUC2mRNA.Patients with positive MUC2mRNA expression in the tumors showed significantly better survival than those with negative MUC2mRNA expression in the tumors.(3) Patterns of MUC5AC (gastric type) and MUC2 (intestinal type) gene expression in "mucin producing tumors of the pancreas (MPTs)", which usually reveal less invasive growth, showed variety among the subtypes of MPTs.(4) In the tumors of pancreas and intrahepatic bile duct, sialic acid epitope of MUC1 mucin seems to play an important role in the invasion growth.(5) In carcinomas of ampulla of Vater and stomach, the patients with MUC1(+) expression showed poorer outcome than those with MUC1(-) expression, whereas the patients with MUC2(+) expression showed more favorable outcome than those with MUC2(-) expression.(6) Significant reduction of pericryptal fibroblast sheath in colorectal epithelial neoplasms reflects progression in the adenoma-carcinoma sequence. Less