Expression of new cell-cell adhesion molecule and mucin genes in cancers : its relationship with invasion or metastasis of cancers

1.鳞状细胞癌(1)S细胞株产生与人内皮细胞株相同的血栓调节蛋白(TM)分子。(2)在口腔和肺SCC中，淋巴结转移灶中TM表达阳性的癌细胞明显少于原发灶。(3)在咽、喉和食道的SCC中，唾液酸化的粘蛋白(DF3抗原)是一种有效的肿瘤标志物。结论：1.食管鳞癌组织中DF3抗原唾液酸寡糖的表达与预后不良有关。腺癌(1)即使在胰腺和肝内胆管的膨胀型生长型肿瘤中，肿瘤的侵袭性生长区也获得了侵袭性生长型肿瘤中常见的MUC1型粘蛋白表达的特征。(2)原位杂交研究发现MUC2型粘蛋白在m…中的表达胰腺和肝内胆管扩张型肿瘤多受MUC2mRNAs调控。MUC2mRNA表达阳性的患者存活率明显高于MUC2mRNA表达阴性的患者。(3)MUC5AC(胃型)和MUC2(肠型)基因在胰腺粘液性肿瘤(MPTS)中的表达模式不同，通常显示侵袭性较小的生长。(4)在胰腺和肝内胆管肿瘤中，MUC1粘蛋白的唾液酸表位似乎在侵袭性生长中起重要作用。(5)在壶腹癌和胃癌中，MUC1粘蛋白的唾液酸表位似乎在侵袭性生长中起重要作用。MUC1(+)表达的患者预后比MUC1(-)表达的患者差，而MUC2(+)表达的患者预后好于MUC2(-)表达的患者。(6)结直肠上皮肿瘤中耻骨周围成纤维细胞鞘的显著减少反映了腺瘤-癌的进展。较少

1. Squamous cell carcinoma(1) Esophageal squamous cell carcinoma (S CC) cell lines produced the same thrombomodulin (TM) molecule as human endothelial cell line. The TM-low-expressing esophageal SCC cells expressed high invasiveness than TM-high-expressing esophageal SCC cells.(2) In SCCs of oral cavity and lung, the tumor cells that were positive for TM expression were significantly rarer in the lymph node metastatic lesions than in the primary tumors.(3) In SCCs of pharynx and larynx, and of esophagus, sialylated MUC1 mucin (DF3 antigen) was an effective tumor marker. The expression of sialyl oligosaccharides of DF3 antigen was related to poor prognosis in esophageal SCCs.2. Adenocarcinoma(1) Even in the expansive growth type tumors of pancreas and intrahepatic bile duct, invasive growth areas of the tumors acquire a characteristic of MUC1 mucin expression that is usually seen in the invasive growth type tumors.(2) In situ hybridization study disclosed that MUC2 mucin expression in m … More ost of expansive growth type tumors of pancreas and intrahepatic bile duct was regulated by MUC2mRNA.Patients with positive MUC2mRNA expression in the tumors showed significantly better survival than those with negative MUC2mRNA expression in the tumors.(3) Patterns of MUC5AC (gastric type) and MUC2 (intestinal type) gene expression in "mucin producing tumors of the pancreas (MPTs)", which usually reveal less invasive growth, showed variety among the subtypes of MPTs.(4) In the tumors of pancreas and intrahepatic bile duct, sialic acid epitope of MUC1 mucin seems to play an important role in the invasion growth.(5) In carcinomas of ampulla of Vater and stomach, the patients with MUC1(+) expression showed poorer outcome than those with MUC1(-) expression, whereas the patients with MUC2(+) expression showed more favorable outcome than those with MUC2(-) expression.(6) Significant reduction of pericryptal fibroblast sheath in colorectal epithelial neoplasms reflects progression in the adenoma-carcinoma sequence. Less