权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

BASICAND CLINICAL RESEARCH ON CONCURRENT CHEMORADIOTHERAPY WITH PROTRACTED LOW DOSE CONTINUOUS INFUSION OF 5-FU + CDDP FOR ESOPHAGEAL CANCER

5-FU CDDP持久低剂量持续输注同步放化疗治疗食管癌的基础与临床研究

基本信息

批准号：
08457240
负责人：
SAKAI Kunio
金额：
$ 3.78万
依托单位：
NIIGATA UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1996
资助国家：
日本
起止时间：
1996 至 1998
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08457240/
关键词：
CHEMORADIOTHERAPY ESOPHAGEAL CANCER 5-FU DDDP 放射線治療増感作用

项目摘要

In the basic study using flow cytometry, a pronounced G_2M phase accumulation of FM3A cells was observed at 72 hours after the combined treatment of 5-FU and CDDP, Most of the cells blocked in G_2 phase for a long time became giant cells or multinuclear cells, which seemed todie later. Combining 5-FU plus CDDP with radiation showed synergistic cytotoxic effect on the experiments using cell growth analysis, dye exclusion test, and morphological analysis.In the clinical study, 31 patients with stage II - III esophageal cancer treated between 1992 and 1994 with the concurrent chemoradiotherapy using low-dose continuous infusion of 5-PU (RT+5FU group) were compared with 27 patients treated previously with radiotherapy alone (RT group). Response rate and local-progression free rate of the RT+5FU group were sigificantly higher than the RT group (p<0.05). Since 1995.32 patients with stage II - III esophageal cancer were treated with the concurrent chemoradiotherapy using low-dose continuous infusion of 5-FU (250 rng/m^2/day) plus CDDP (3 mg/m^2/day) (RTFC group). The RT+FC group showed response rate, local-progression free rate, and cummulative survival rate to be significantly higher than the RT group (p<0.05). We conclude that low-dose continuous infusion of 5-FU*CCDDP given during entire course of conventional radiotherapy is significantly superior to conventional radiotherapy alone in the local control of stage II - III esophageal cancer.

在流式细胞术的基础研究中，5-FU和CDDP联合作用72小时后，FM 3A细胞出现明显的G_2M期聚集，大多数细胞在G_2期阻滞较长时间后变成巨细胞或多核细胞，并有后期死亡的趋势。细胞生长分析、染料排斥试验和形态学分析显示，5-FU + CDDP联合放疗具有协同细胞毒作用。1992年至1994年期间，31例II - III期食管癌患者采用低剂量持续输注5-PU同步放化疗治疗RT+5 FU组与单纯放疗组（RT组）比较。RT+5 FU组的有效率和局部无进展率明显高于RT组（p<0.05）。自1995年以来，对32例Ⅱ ~ Ⅲ期食管癌患者采用小剂量5-FU（250 mg/m2/d）持续输注加顺铂（3 mg/m2/d）同步放化疗（RTFC组）。RT+FC组的有效率、局部无进展率和累积生存率均显著高于RT组（p<0.05）。我们得出结论，在整个常规放疗过程中给予5-FU*CCDDP的低剂量持续输注在II - III期食管癌的局部控制方面显著上级单独的常规放疗。