Neuronal network of dreaming sleep in human : A positron CT study

工作背景：为了阐明非快速眼动（NREM）和快速眼动睡眠和神经相关的功能，在这些睡眠条件下，测量局部脑血流量（rCBF）的高分辨率正电子发射断层扫描（PET）沿着与多导睡眠图（PSG）在人类sleep.Methods：五个年轻的，健康的，右利手的男性受试者参加了这项研究。每个受试者在实验之夜前都被剥夺了睡眠。结果：与清醒状态相比，NREM睡眠时桥脑和小脑的rCBF明显降低，慢波睡眠时下降更明显，REM睡眠时恢复正常。在NREM睡眠期，颞叶、额叶和顶叶皮质的rCBF轻度下降，扣带回中度下降，丘脑显著下降，REM睡眠期恢复。在一个受试者的枕叶皮层的rCBF出现增加，在REM睡眠时相比，清醒restingstates.These结果表明，NREM睡眠是一个休息状态与广泛的抑郁症的大脑功能，而REM睡眠是一个激活状态与不同的模式，比清醒的大脑功能。此外，脑干-丘脑皮质激活系统的神经功能抑制可能主要参与了NREM睡眠的诱导。

Background : To clarify the functions of non-REM (NREM) and REM sleep and neural correlates during these sleep conditions, measurements of regional cerebral blood flow (rCBF) by a high-resolution positron emission tomography (pet) along with polysomnography (PSG) were undertaken during human sleep.Methods : Five young, healthy, right-handed male subjects participated in this study. Each subject was totally sleep deprived preceding the experimental night. Measurements of rCBF were made using bolus intravenous injections of H2150 scheduled during NREM sleep, REM sleep and wake-fulness under PSG monitoring.Results : The rCBF decreased markedly in the pons and moderately in the cerebellum during NREM sleep, especially during slow wave sleep (SWS) as compared with awake resting state, and recovered during REM sleep. They rCBF declined slightly in the temporal, frontal and parietal cortices, moderately in the cingulate gyrus, markedly in the thalamus during NREM sleep, and recovered during REM sleep. The rCBF in the occipital cortex in a subject appeared to be increased during REM sleep when compared to awake resting state.These results suggest that NREM sleep is a resting state with generalized depression of brain function, while REM sleep is an activated state with a different pattern of brain function than wakefulness. Furthermore, depressed neural functions in the brainstem-thalamocortical activating system may mainly be involved in the induction of NREM sleep.