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Basic Research for Prevention of Myocardial Infarction during Dental Treatment

牙科治疗中预防心肌梗塞的基础研究

基本信息

批准号：
08457542
负责人：
ITO Hiromichi
金额：
$ 4.22万
依托单位：
TOKYO MEDICAL AND DENTAL UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1996
资助国家：
日本
起止时间：
1996 至无数据
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08457542/
关键词：
ATP adenosine colored microspheres myocardial infarction dental treatment nitric oxide concentration

项目摘要

In the advent of the society of aged people, the most aged dental patients have many complications. The serious diseases among them are a silent angina pectoris and a myocardial infarction. It is nessesary to prevent the incidence of such a cardiogenic shock during dental procedures.ATP as a potent vasodilator both in animals and human beings has been used for hypotensive anesthesia by us. So we expect that the administration of ATP to the patients with the myocardial infraction or the silent angina pectoris will be useful to prevent the heart attack during dental treatments.The aim of this basic research is to detect the coronary vasodilative effects of ATP on the opened beating heart in rabbit.The regional blood flow (RBF) was measured in the heart by the colored microspheres method. The myocardial tissue oxygen tension (Pt02) and nitric oxygen tension (CtNO) were also determined in the left ventricular myocardium by the polarography method to evaluate the effect of ATP.ATP or glycerin trinitrate (TNG) was administrated after 15 minutes' ligation of left descending coronary artery. The administration of ATP more increased both RBF amd Pt02 than the administration of TNG.Also ATP controlled minimum release of CtNO from the left ventricular myocardium.These results suggest that a coronary stenosis and infarction in a case of the acute myocardial attack might be effectively reperfused by ATP.We would like to try further investigations so as to use ATP to dental patients.

随着老年人社会的到来，老年口腔患者的并发症也越来越多。其中严重的疾病是无症状心绞痛和心肌梗塞。ATP作为一种强有力的血管扩张剂，在动物和人体中已被我们用于扩张麻醉。本实验采用家兔心脏不停跳开放模型，用彩色微球法测定心脏局部血流量，观察ATP对心脏的舒张作用，并与对照组比较，结果表明ATP对心脏局部血流量有明显的舒张作用。用极谱法测定左室心肌组织氧分压（Pt02）和一氧化氮分压（CtNO），以评价ATP的作用。结果表明，ATP对急性心肌梗塞和冠状动脉狭窄有较好的再灌注作用，ATP对心肌梗塞和冠状动脉狭窄的再灌注作用优于TNG，ATP对心肌梗塞和冠状动脉狭窄的再灌注作用优于TNG，ATP对急性心肌梗塞和冠状动脉狭窄的再灌注作用优于TNG，ATP对急性心肌梗塞和冠状动脉狭窄的再灌注作用优于TNG，ATP对急性心肌梗塞和冠状动脉狭窄的再灌注作用优于TNG。