RISK FACTOR OF ORAL LICHEN PLANUS.-COHORT STUDY FOR FEMALE WITH LOW SERUM CAROTENOID LEVEL

口腔扁平苔藓的危险因素-低血清类胡萝卜素水平女性队列研究

• 批准号: 08457560
• 负责人: NAGAO Toru
• 金额: $ 4.67万
• 依托单位: AICHIGAKUIN-UNIVERSITY SCHOOL OF DENTISTRY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08457560/
• 关键词: beta-carotene; oral lichen planus; cohort study; epidemiology; ベーターカロチン; 扁平苔癬; ベータ-カロチン; βカロテン; 白板症

A Malaysian study on serum micronutrients of beta -carotene on oral cancer and precancer/precancerous condition patients had shown significantly inverse associations between serum levels of micronutrients and oral cancer and precancer. The purpose of this study is to show the relationship between serum carotenoid levels and the occurrence of oral lichen planus by cohort study in Japanese female of a city in Japan.Nine hundred and thirty four female residents of over 40 years of age who were found without no lesion and no smoking were registered as an cohort during an annual health screening of 3273 residents as preliminary study in 1995. Serum beta -carotene was analyzed, and the cohort was divided into three groups according to the beta -carotene level ; low, middle and high level group. Occurrence of oral lichen planus was checked during an annual oral health screening for 3 years from 1996 to 1998.One case in the low group, 2 cases in middle group and 3 cases in high group were detected as positive oral lichen planus. There was no significant difference in any of the serum micronutrient levels among oral lichen planus cases. It is suggested that there was no relationship between low serum beta -carotene level and the occurrence of oral lichen planus.

马来西亚一项关于口腔癌和癌前病变患者血清微量营养素β -胡萝卜素的研究显示，血清微量营养素水平与口腔癌和癌前病变之间存在显著的负相关。本研究通过对日本某城市女性进行队列研究，探讨血清类胡萝卜素水平与口腔扁平苔藓发生的关系。1995年对3273名居民进行了年度健康检查，登记了934名40岁以上无病变、不吸烟的女性居民作为队列，作为初步研究。分析血清β -胡萝卜素，按β -胡萝卜素水平将队列分为三组；低、中、高水平组。在1996年至1998年3年的年度口腔健康检查中检查口腔扁平苔藓的发生情况。低组1例、中组2例、高组3例口腔扁平苔藓阳性。口腔扁平苔藓患者血清微量营养素水平无显著差异。提示血清β -胡萝卜素水平低与口腔扁平苔藓的发生无关系。

项目成果

Zain R B,Fukano H,Razak I A,Shanmuhasuntharam P,Ikeda N,Rahman Z A A,Ghazali M N,Yano M,Nagao T,Ito Y,Miyazaki H: "Risk factors for oral leukoplakia : A comparison of two ethnic groups in Malaysia." Oral Oncology Macmillan India. Vol VI. 207-210 (1999)

Zain R B、Fukano H、Razak I A、Shanmuhasuntharam P、Ikeda N、Rahman Z A A、Ghazali M N、Yano M、Nagao T、Ito Y、Miyazaki H：“口腔白斑的危险因素：马来西亚两个种族的比较。”

Zain R B,Rahman Z A A,Fukano H,Nagao T,Abang Z,Razak I A,Ikeda N,Yano M,Ito Y,Miyazaki H: "Oral Habits, Serum micronutrients and oral mucosal lesions among the indigenous people of Sarawak." Oral Oncology Macmillan India. Vol VI. 185-188 (1999)

Zain R B、Rahman Z A A、Fukano H、Nagao T、Abang Z、Razak I A、Ikeda N、Yano M、Ito Y、Miyazaki H：“砂拉越原住民的口腔习惯、血清微量营养素和口腔粘膜病变。”

Zain RB, et al: "Oral Habits, Serum micronutrients and oral mucosal lesions among the indigencus people of Sarawak." Oral Oncology Vol VI Macmillan Indin. VI. 185-188 (1999)

Zain RB 等人：“砂拉越原住民的口腔习惯、血清微量营养素和口腔粘膜病变。”

Zain RB, et al: "Risk factors for Oral, leukoplakia : A comparison of two ethnic group in Malaysin" Oral Oncology Macmillan Indin. VI. 207-210 (1999)

Zain RB 等人：“口腔白斑的风险因素：马来西亚两个种族群体的比较”口腔肿瘤学 Macmillan Indin。