RISK FACTOR OF ORAL LICHEN PLANUS.-COHORT STUDY FOR FEMALE WITH LOW SERUM CAROTENOID LEVEL

马来西亚对口腔癌和癌前/癌前状态患者血清β-胡萝卜素微量营养素的研究表明，血清微量营养素水平与口腔癌和癌前状态之间存在显著的负相关性。为探讨血清类胡萝卜素水平与口腔扁平苔藓发生的关系，对1995年在日本某城市进行的3273名居民的年度健康筛查中，934名年龄在40岁以上、无病变、不吸烟的女性居民进行了队列研究。分析血清β-胡萝卜素，并根据β-胡萝卜素水平将队列分为三组：低、中、高水平组。1996 ~ 1998年连续3年进行口腔健康普查，检出口腔扁平苔藓1例，中2例，高3例。口腔扁平苔藓患者血清微量营养素水平无显著差异。提示低血清β-胡萝卜素水平与口腔扁平苔藓的发生无关。

A Malaysian study on serum micronutrients of beta -carotene on oral cancer and precancer/precancerous condition patients had shown significantly inverse associations between serum levels of micronutrients and oral cancer and precancer. The purpose of this study is to show the relationship between serum carotenoid levels and the occurrence of oral lichen planus by cohort study in Japanese female of a city in Japan.Nine hundred and thirty four female residents of over 40 years of age who were found without no lesion and no smoking were registered as an cohort during an annual health screening of 3273 residents as preliminary study in 1995. Serum beta -carotene was analyzed, and the cohort was divided into three groups according to the beta -carotene level ; low, middle and high level group. Occurrence of oral lichen planus was checked during an annual oral health screening for 3 years from 1996 to 1998.One case in the low group, 2 cases in middle group and 3 cases in high group were detected as positive oral lichen planus. There was no significant difference in any of the serum micronutrient levels among oral lichen planus cases. It is suggested that there was no relationship between low serum beta -carotene level and the occurrence of oral lichen planus.