Development of multiple channeled recording system for somatosensory evoked potendiuls by human dental stimulation

人体牙齿刺激体感诱发电位多通道记录系统的开发

• 批准号: 08557112
• 负责人: UMINO Masahiro
• 金额: $ 12.74万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08557112/
• 关键词: SEP; Dental stimulation; Pain intensity; Randomized order; 電気刺激; 広範囲侵害抑制性調節

PurposeWe developed a new system of recording somatosensory evoked potentials (SEPs) by randomized electrical tooth stimulation with multiple levels of intensity. The purpose of this study was to determine whether SEPs produced by the dental stimulation with 3, 4 and 6 different levels of intensity are recorded corresponding to stimules intensity in healthy volunteers.MethodsThe SEPs recording system is composed of SEps recording system, constant-current isolator and stimulator and . computer. The system can automatically generate the dental simulation with 8 levels of intensity through the constant-current isoiator at randomized order. Healthy volunnteers obtained informed consent were subjects. These subjects were divided into three groups. Group I had 3 levels of intensity. Group II and III were with 4 and 6. levlels of intensity respectively. A healthy, unfilled upper central incisor was selected fort' the study. SEPs were recorded from Cz through dental electrical stimulation. Sixty four evoked potentials were summed and averaged for each of the 3, 4 and 6 different intensity levels.Results1) The late component with a latency between 150 and 250 msec was corresponded to stimulus intensity in group I and II.2) The late component with a latency between 150 and 250 msec showed the relation with pain intensity in group I.3) The relation between stimulus intensity and pain intensity was observed.4) It was seggested that this system can be applied for clinical use.We could record SEPs wave form corresponded to multiple stimulus intensity using this systerm. The system is expected to be appropriate for evaluating the analgesic effects of analgesics or anesthetics and elucidating the pain mecanism or psychological changes.

目的我们开发了一种新系统，通过多级强度的随机电牙齿刺激来记录体感诱发电位（SEP）。本研究的目的是确定健康志愿者接受3、4、6种不同强度的牙齿刺激所产生的SEPs是否能够被记录到与刺激强度相对应的SEPs。方法SEPs记录系统由SEps记录系统、恒流隔离器和刺激器组成。电脑。系统可以通过恒流隔离器按随机顺序自动生成8级强度的牙科模拟。获得知情同意的健康志愿者为受试者。这些受试者被分为三组。第一组有 3 个强度级别。第二组和第三组分别为4级和6级强度。研究中选择了一颗健康的、未填充的上中切牙。通过牙科电刺激从 Cz 记录 SEP。对 3、4 和 6 个不同强度水平中的每一个的 64 个诱发电位进行求和并平均。 结果 1) 潜伏期在 150 到 250 msec 之间的晚期成分对应于 I 组和 II 组中的刺激强度。 2) 潜伏期在 150 到 250 msec 之间的晚期成分显示了 I 组中的疼痛强度的关系。 3) 观察了刺激强度和疼痛强度之间的关系。 表明该系统可以应用于临床。使用该系统可以记录多种刺激强度对应的SEPs波形。该系统预计适用于评估镇痛药或麻醉药的镇痛效果，并阐明疼痛机制或心理变化。

项目成果

Masahiro Umino., Katsunori Motohashi.: "Somatosensory Evoked Potentials Recording by Randomized Electrical Tooth Stimulation with Different Levels of Intensity." 9th World Congress on Pain. (in printing). (1999)

Masahiro Umino.、Katsunori Motohashi.：“通过不同强度的随机牙齿电刺激记录体感诱发电位。”

海野雅浩 元橋功典: "刺激強度のランダム化を図ったSEP記録システム" Pain Research. 13・3. 137 (1998)

Masahiro Unno 和 Yoshinori Motohashi：“刺激强度随机化的 SEP 记录系统”疼痛研究 13・3（1998）。

元橋功典・海野雅浩: "侵害刺激による鎮痛発現と刺激部位の影響" 第46回日本麻酔学会発表予定.

Yoshinori Motohashi 和 Masahiro Unno：“有害刺激引起的镇痛表达和刺激部位的影响”预定在第 46 届日本麻醉医师学会上发表演讲。

Katsunori Motohashi., Masahiro Umino.: "Inhibition of Evoked Potentials criginated from electrical tooth stimuration by extrasegmental noxious." Journal of Anesthesia.Volume 12. 241 (1998)

Katsunori Motohashi.，Masahiro Umino.：“节段外有害物质对牙齿电刺激引起的诱发电位的抑制。”

Tomotada Hokazono., Noburou Katakura., Masahiro Umino.: "Effects of Spinal Noxious Stimulation on Trigeminal Reflex Responses in an in vitro Brainstem-Spinal Cord Preparation from Newborn Rats" Japanese Journal of Oral Biology.Volume 14. 204 (1998)

Tomotada Hokazono.、Noburou Katakura.、Masahiro Umino.：“脊髓有害刺激对新生大鼠体外脑干脊髓制备中三叉神经反射反应的影响”日本口腔生物​​学杂志.卷 14. 204 (1998)