Regulatory roles of the RNA helicase DDX5 in male germline stem cells

RNA解旋酶DDX5在雄性生殖干细胞中的调节作用

• 批准号: DP220103555
• 负责人: A/Prof Robin Hobbs
• 金额: $ 40.83万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-07-12 至 2025-07-11
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220103555
• 关键词: Regulatory; roles; RNA; helicase; DDX5

This project aims to investigate the role of the RNA helicase DDX5 in regulating gene expression programs of male germline stem cells by utilising novel mouse models, stem cell culture and genome-wide analysis approaches. This project expects to generate new knowledge in the area of germline maintenance and adult stem cells using innovative in vivo and in vitro experimental systems. Expected outcomes of this project will include gain of substantial insight into molecular mechanisms underlying germline stem cell function and gene regulation within the male germline. This should provide significant benefits, including advancement of reproductive science and development of systems applicable for animal germline preservation and manipulation.

该项目旨在通过利用新型小鼠模型，干细胞培养和全基因组分析方法来研究RNA解旋酶DDX 5在调节雄性生殖干细胞基因表达程序中的作用。该项目预计将产生新的知识，在生殖系维护和成人干细胞领域使用创新的体内和体外实验系统。该项目的预期成果将包括获得对生殖系干细胞功能和男性生殖系内基因调控的分子机制的实质性见解。这将带来巨大的好处，包括生殖科学的进步和适用于动物生殖系保存和操作的系统的发展。