Genetic control of germline progenitor cell heterogeneity and fate

生殖祖细胞异质性和命运的遗传控制

• 批准号: FT140101029
• 负责人: A/Prof Robin Hobbs
• 金额: $ 53.22万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-07-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT140101029
• 关键词: Genetic; control; germline; progenitor; cell

Tissue maintenance in adults is dependent on resident stem cells, defined by self-renewal and differentiation capabilities. It is apparent that stem cell populations are heterogeneous, being composed of subpopulations with distinct properties. The functional significance of these subsets and mechanisms that control their divergent characteristics are unclear. Using germline stem cells from mice as a model, stem cell subsets have been identified based on differential expression of the pluripotency gene Pou5f1. This project aims to define functional characteristics of these subpopulations and to dissect transcription factor networks controlling their development. This promises important insights into understandings of adult stem cell regulation.

成人的组织维持依赖于由自我更新和分化能力定义的常驻干细胞。很明显，干细胞群体是异质的，由具有不同性质的亚群组成。这些亚群的功能意义和控制其不同特征的机制尚不清楚。使用来自小鼠的生殖系干细胞作为模型，已经基于多能性基因Pou5f1的差异表达鉴定了干细胞亚群。该项目旨在确定这些亚群的功能特征，并剖析控制其发育的转录因子网络。这为理解成体干细胞调控提供了重要的见解。