Adaptation by DNA download: Experimental evolution of a pangenome

DNA 适应下载：泛基因组的实验进化

• 批准号: DP220103548
• 负责人: A/Prof Michael McDonald
• 金额: $ 25.67万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-03-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220103548
• 关键词: Adaptation; DNA; download; Experimental; evolution

This project aims to understand how microbes adapt when they can directly “download" new genes from their surrounding environment, or from other types of bacteria. Specifically, the proposed research will carry out the largest-scale measurements of the fitness effects of horizontally transferred genetic variation, to discover how each of these genes interacts with the environment, and with other genes. This project is expected to generate new knowledge in the fields of microbial evolution and microbiome science. The benefits of this cutting-edge research will be to strengthen Australia’s research capacity in these rapidly developing fields and to train a new generation of interdisciplinary scientists.

该项目旨在了解微生物在能够直接从周围环境或其他类型的细菌中“下载”新基因时如何适应。具体来说，拟议的研究将对水平转移遗传变异的适应度效应进行最大规模的测量，以发现这些基因中的每一个如何与环境以及其他基因相互作用。该项目预计将产生微生物进化和微生物组科学领域的新知识。这项尖端研究的好处将是加强澳大利亚在这些快速发展领域的研究能力，并培养新一代跨学科科学家。