Tracking the molecular dynamics of adaptation with horizontal gene transfer

通过水平基因转移追踪适应的分子动力学

• 批准号: FT170100441
• 负责人: A/Prof Michael McDonald
• 金额: $ 49.47万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-07-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT170100441
• 关键词: Tracking; molecular; dynamics; adaptation; horizontal

This project aims to track the dynamics of adaptation with gene exchange by building the first experimental evolution model that can directly observe this process. The acquisition of genes from other strains and species (horizontal gene transfer) frequently underlies bacterial adaptation, but it is unknown how this occurs. This project aims to shift understanding of how microbial populations respond to environmental challenges. There are significant benefits to be gained from understanding how microbes adapt in response to climate change and the widespread application of antibiotics, given that microbial populations form intimate associations with humans and sustain all of the world’s ecosystems.

该项目旨在通过建立第一个可以直接观察这一过程的实验进化模型来跟踪基因交换的适应动态。从其他菌株和物种获得基因（水平基因转移）通常是细菌适应的基础，但尚不清楚这是如何发生的。该项目旨在改变对微生物种群如何应对环境挑战的理解。了解微生物如何适应气候变化和抗生素的广泛应用将带来重大益处，因为微生物种群与人类形成密切联系并维持世界所有生态系统。