Protective immune responses in enteromucosa tissues of cats infected with Toxoplasma gondii
Protective immune responses in enteromucosa tissues of cats infected with Toxoplasma gondii
批准号:
08660376
负责人:
OMATA Yoshitaka
金额:
$1.66万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
1996
资助国家:
日本
项目状态:
已结题
起止时间:
1996 至 1997
中文摘要
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英文摘要
1) Identification of interleukin 12 in various tissue organs of cats infected with Toxoplasma gondii ; Interleukin 12 -35kD and -40 kD subunits of cats were identified by RT-PCR.In the spleen and mesenteric lymphnodes of cats reinfected with T.gondii, IL-12 40kD subunit was expressed transiently post reinfection.2) Detection of secretory IgA and its protective roles in enteromucosa tissues of cats ; Anti-T.gondii antibody IgA was detected in feces and intestinal washings ofcats infected with T.gondii. Supplement of the washings in the culture medium suppressed the parasite penetration activity of feline embryonic fibroblasts.3) Stage-spcific antigens associated with gametogenesis of Toxoplasma gondii ; Enteroepithelial stage parasites were isolated by Percoll density gradient centrifugation. Enteroepithelial stage parasite specific antigens were detected by antisera of mice and cats immunized with the parasites.
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Yoshitaka OMATA, et al.: "Isolation of coccidian enteroepithelial stages of Toxoplasma gondii from the intestinal mucosa of cats by Percoll density gradient centrifugation" Parasitology Research. 83. 574-577 (1997)
Yoshitaka OMATA 等人:“通过 Percoll 密度梯度离心从猫的肠粘膜中分离弓形虫的球虫肠上皮阶段”寄生虫学研究。
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发表时间:
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影响因子:
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作者:
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通讯作者:
Yoshitaka OMATA, et al.: "Positive evidence that anti-Toxoplasma gondii IgA antibody exists in the intestinal tract of infected cats and exerts positive activitv against the infection" Veterinary Parasitology. 73. 1-11 (1997)
Yoshitaka OMATA 等人:“积极证据表明,受感染猫的肠道中存在抗弓形虫 IgA 抗体,并对感染发挥积极活性”《兽医寄生虫学》。
DOI:
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发表时间:
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影响因子:
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作者:
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通讯作者:
Yoshitaka OMATA et al.: "Positive evidence that anti-Toxoplasma gondii IgA antibody exists in the intestinal tract of infected cats and exerts positive activity against the infection." Veterinary Parasitology. 73. 1-11 (1997)
Yoshitaka OMATA 等人:“积极证据表明,受感染猫的肠道中存在抗弓形虫 IgA 抗体,并对感染发挥积极活性。”
DOI:
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发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
Yoshitaka OMATA et al.: "Isolation of coccidian enteroepithelial stages of Toxoplasma gondii from the intestinal mucosa of cats by Percoll density gradient centrifugation." Parasitology Research. 83. 574-577 (1997)
Yoshitaka OMATA 等人:“通过 Percoll 密度梯度离心从猫的肠粘膜中分离弓形虫的球虫肠上皮阶段。”
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
Yoshitaka OMATA: "Isolation of coccidian enteroepithelial stages of Toxoplasma gondii from the intestinal mucosa of cats by Percoll density gradient centrifugation" Parasitology Research. (印刷中).
Yoshitaka OMATA:“通过 Percoll 密度梯度离心从猫的肠粘膜中分离出弓形虫的球虫肠上皮阶段”寄生虫学研究(正在出版)。
DOI:
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发表时间:
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影响因子:
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作者:
[]
通讯作者:
共 7 条
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