Hunger flexibly modifies hypothalamic neural circuits responding to threat.

饥饿会灵活地改变下丘脑神经回路对威胁的反应。

• 批准号: DP220102567
• 负责人: Prof Zane Andrews
• 金额: $ 52.94万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-05-23 至 2026-05-22
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220102567
• 关键词: Hunger; flexibly; modifies; hypothalamic; neural

Animal and human behaviour frequently involves a choice between actions or goals with conflicting positive and negative outcomes. However, the appropriate action or goal in conflicting situations often depends on physiological pressures like hunger, stress and mating opportunities. For example, the need for resources within an environment, such as food, drives approach behaviour, whereas threats to survival, such as predator cues, enhance avoidance behaviour. This project will uncover the neural circuitry and endocrine mechanisms through which hunger influences hypothalamic threat-detecting circuits that suppress food intake. These studies provide a new hypothalamic model to understand risk/reward decision in the brain.

动物和人类的行为经常涉及在积极和消极结果相互冲突的行动或目标之间做出选择。然而，在冲突的情况下，适当的行动或目标往往取决于生理压力，如饥饿、压力和交配机会。例如，对环境中资源的需求，如食物，会驱使它们接近行为，而对生存的威胁，如捕食者的暗示，会增强回避行为。这个项目将揭示神经回路和内分泌机制，饥饿通过这些机制影响下丘脑抑制食物摄入的威胁检测电路。这些研究为理解大脑中的风险/回报决策提供了一个新的下丘脑模型。