Identification of the molecular epitope associated with mesangical cell function.

在肾小球中，毛细血管内区域是由肾小球基底膜包围的封闭空间，所述肾小球基底膜由毛细血管腔、内皮细胞（EC）、系膜细胞（MC）和系膜基质组成。我们的工作假设是，由intrinsicECs和/或基质的物理和功能调节的损失可能会导致MCs功能障碍，导致病理变化，如增殖，增强细胞外基质的合成，MCs迁移和系膜介入毛细血管区域。本研究在1996 -1997年教育科学文化部研究基金（No.08670241，1996 -1997）的资助下，取得了如下研究成果：

In the glomerulus, the endocapillary region is a closed space surrounded by the glomerular basement membrane comprised of a capillary lumen, endothelial cells (ECs), mesangical cells (MCs), and mesangical matrices. Our working hypothesis is that loss of physical and functional regulation by intrinsicECs and/or matrices may induce MCs dysfunction, leading to the pathological changes such as proliferation, enhanced extracellular matrix synthesis, MCs migration and mesangical interposition in the capillary region. By the aid of reseach grant (No.08670241,1996-1997) from the Ministry of Education, Science and Culture, we have got the results summarized up as the followings ;