Identification of the molecular epitope associated with mesangical cell function.

与系膜细胞功能相关的分子表位的鉴定。

• 批准号: 08670241
• 负责人: OITE Takashi
• 金额: $ 1.47万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08670241/
• 关键词: renal glomerulus; mesangial cell; vascular endothelial cell; extracellular matrix; cell adhesion molecules; cell-cell interction; regulation of cell function; 混合培養; メリンギウム細胞

In the glomerulus, the endocapillary region is a closed space surrounded by the glomerular basement membrane comprised of a capillary lumen, endothelial cells (ECs), mesangical cells (MCs), and mesangical matrices. Our working hypothesis is that loss of physical and functional regulation by intrinsicECs and/or matrices may induce MCs dysfunction, leading to the pathological changes such as proliferation, enhanced extracellular matrix synthesis, MCs migration and mesangical interposition in the capillary region. By the aid of reseach grant (No.08670241,1996-1997) from the Ministry of Education, Science and Culture, we have got the results summarized up as the followings ;

在肾小球中，毛细血管内区是一个由肾小球基底膜包围的封闭空间，由毛细血管腔、内皮细胞（EC）、系膜细胞（MC）和系膜基质组成。我们的工作假设是，由intrinsicECs和/或基质的物理和功能调节的损失可能会导致MCs功能障碍，导致病理变化，如增殖，增强细胞外基质的合成，MCs迁移和系膜介入毛细血管区域。本研究在1996 -1997年教育科学文化部研究基金（No.08670241，1996 -1997）的资助下，取得了如下研究成果：

项目成果

Narisawa-Saito,M.et.al: "Thy-1 molecule associates with protein tyrosine kinase in rat …‥" Clin.exp.Immunol.106. 86-90 (1996)

Narisawa-Saito,M.et.al：“Thy-1 分子与大鼠中的蛋白酪氨酸激酶相关……”Clin.exp.Immunol.106 (1996)。

M.Narisawa-Saito et.al: "Thy-1 molecule transduces cell-signals associated with protein-tyrosine kinase such as p59fyn and p56/53lyn" Clin exp Immunol. 106. 86 (1996)

M.Narisawa-Saito 等人：“Thy-1 分子转导与蛋白酪氨酸激酶（例如 p59fyn 和 p56/53lyn）相关的细胞信号”Clin exp Immunol。

S.Omori et.al: "Quantification of apoptotic cells using isolated glomeruli." Nephron. 77. 474-478 (1997)

S.Omori 等人：“使用分离的肾小球对凋亡细胞进行定量。”

M.Narisawa-Saito et.al: "Thy-1-mediated phosphatidylinositol turnover in cultured rat glomerular mesangial cell." J Cell Physiol. 168. 705-710 (1996)

M.Narisawa-Saito 等人：“培养的大鼠肾小球系膜细胞中 Thy-1 介导的磷脂酰肌醇周转。”

追手巍,他: "血管内皮細胞による周細胞の機能抑制-腎糸球体をモデルとして-" 新潟医学会雑誌. 110. 207-209 (1996)

Oete 等人：“血管内皮细胞对周细胞功能的抑制 - 使用肾小球作为模型”Niigata Medical Society Journal 110. 207-209 (1996)。