MECHANISM OF B-CELL POSITIVE SELECTION IN THE BURSA OF FABRICIUS

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B-cell repertoire in the bursa of Fabricius is diversified by gene conversion. We speculate that mutated B cells would be selected in the bursa of Fabricius in situ by corresponding antigens derived from the gut. In our experiments, environmental antigens derived from the gut made immune complex with maternal IgG in the bursal follicles. The distribution of antigen-antibody complex showed dendritic appearances in the medulla of bursal follilces. These results suggest that antigen-antibody complex trapped by FDC (Follicular Dendritic Cells), plays an important role in positive selection of B cells in the bursa of Fabricius.