MECHANISM OF B-CELL POSITIVE SELECTION IN THE BURSA OF FABRICIUS

法氏囊B细胞正选择机制

• 批准号: 08670371
• 负责人: EKINO Shigeo
• 金额: $ 1.28万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08670371/
• 关键词: Immunity; B cell; the bursa of Fabricius; Maternalantibody; IgG; ファブリキウス嚢; アポトーシス

B-cell repertoire in the bursa of Fabricius is diversified by gene conversion. We speculate that mutated B cells would be selected in the bursa of Fabricius in situ by corresponding antigens derived from the gut. In our experiments, environmental antigens derived from the gut made immune complex with maternal IgG in the bursal follicles. The distribution of antigen-antibody complex showed dendritic appearances in the medulla of bursal follilces. These results suggest that antigen-antibody complex trapped by FDC (Follicular Dendritic Cells), plays an important role in positive selection of B cells in the bursa of Fabricius.

法氏囊中的B细胞库通过基因转换而多样化。我们推测，突变的B细胞将在法氏囊原位被来自肠道的相应抗原选择。在我们的实验中，来自肠道的环境抗原与法氏囊滤泡中的母体IgG形成免疫复合物。抗原抗体复合物在法氏囊滤泡髓质呈树枝状分布。这些结果表明，被滤泡树突状细胞（FDC）捕获的抗原抗体复合物在法氏囊B细胞的正选择中起重要作用。

项目成果

浴野成生: "Oligoclonal development of B-cells bearing discrete Ig chains in chicken single germinal centers" J.Immunol.(in press). (1998)

Nario Yukino：“鸡单一生发中心中带有离散 Ig 链的 B 细胞的寡克隆发育”J.Immunol.（出版中）。

:浴野 成生: "Oligoclonal development of B-cells bearing discrete Ig chains in chicken single germinal centers" J.Immunol.(in press). (1998)

：Naruo Yukino：“鸡单生发中心中带有离散 Ig 链的 B 细胞的寡克隆发育”J.Immunol.（出版中）。

浴野成生: "A Comparative study of germinal center:fowl and mammal" Comparative Immunology Microbiology & Infectious Diseases. (in press). (1998)

Nario Yukino：“生发中心的比较研究：家禽和哺乳动物”比较免疫学微生物学和传染病（出版中）。