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Studies on the increased incidence rate of colon cancer due to the excess intake of water soluble dietary fiber

过量摄入水溶性膳食纤维导致结肠癌发病率增加的研究

基本信息

批准号：
08670465
负责人：
NISHIMUNE Takahiro
金额：
$ 1.47万
依托单位：
Musashigaoka college
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1996
资助国家：
日本
起止时间：
1996 至 1998
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08670465/
关键词：
dietary fiber soluble dietary fiber colon cancer dimethylhydrazine rat chemical carcinogenesis intake ratio serum cholesterol dietary fiber colon cancer water insoluble dietary fiber water soluble dietary fiber intake ratio water

项目摘要

In order to make clear whether it is necessary to lay a guideline for the intake ratio of water souble dietary fiber to the water insoluble one, we investigated the effect of feeding guar gum or guar gum plus cellulose on the chemical carcinogenesis by 1,2-dimethylhydrazine of rat colon. The results obtained were as follows.1. We confirmed the precedent reports indicating the enhancement of tumor formation by feeding guar gum with statistical significance.2. We disclosed the fact that the enhanced tumor formation was suppressed completely when 2/3 of the guar gum was replaced with cellulose.3. In both cases of 1. and 2.,serum cholesterol and tryglyceride levels were decreased significantly, and fecal excretion per day of total bile acids were almost doubled.4. In the case of 1., the fecal concentration of total bile acids was in the same level to or significantly higher than the control (no dietary fiber fed). In the case of 2., however, the fecal concentration of total bile acids was significantly lower than or almost half of the control.5. In the case of 1., de-conjugation activities were higher, and in the case of 2., they were lower than the control group. Accordingly, the de-conjugation of the excretion form of DMH to the digestive tract, the glucuronate conjugate of methylazoxymethanol was deduced to be more complete in the case 1. when compared with the case 2 rats.6. 7-α-dehydroxylation activity was deduced to be lower in the case 1. rats than the control or case 2. rats on the fact that the amount of lactate, acetate or propionate detected in the cecum was almost double in the case 1. compared to the control rats or case 2. rats. Consequently, the concentration of fecal secondary bile acids of case 1. rats was the lowest among other groups and the neoplasma detected in case 1. rats were all adenoma. Thus, it is to be desired that the guideline for balanced intake of dietary fiber is officially published.

为了明确是否有必要制定水溶性膳食纤维与水不溶性膳食纤维的摄入比例准则，我们研究了饲喂瓜尔胶或瓜尔胶加纤维素对大鼠结肠1,2-二甲基肼化学致癌作用的影响。得到的结果如下： 1．我们证实了先前的报道，表明喂食瓜尔胶可以促进肿瘤形成，具有统计学意义。2．我们揭示了当2/3的瓜尔胶被纤维素取代时，增强的肿瘤形成被完全抑制。3．在1.和2.两种情况下，血清胆固醇和甘油三酯水平均显着降低，每天从粪便中排出的总胆汁酸几乎增加了一倍。4.在1.的情况下，总胆汁酸的粪便浓度与对照（未喂食膳食纤维）处于相同水平或显着高于对照。然而，在2.的情况下，总胆汁酸的粪便浓度显着低于或几乎是对照的一半。5。在1.的情况下，解结合活性高于对照组，而在2.的情况下，解结合活性低于对照组。因此，与病例2大鼠相比，病例1中DMH的排泄形式甲基偶氮甲醇的葡萄糖醛酸结合物到消化道的去结合更加完全。 6．与对照大鼠或病例2大鼠相比，在病例1.大鼠的盲肠中检测到的乳酸、乙酸盐或丙酸盐的量几乎是两倍，因此推断病例1.大鼠的7-α-脱羟基活性低于对照或病例2.大鼠。因此，病例1大鼠粪便次级胆汁酸浓度是其他组中最低的，病例1大鼠检测到的肿瘤均为腺瘤。因此，膳食纤维均衡摄入指南亟待正式出台。