EFFECT OF HELICOBACTER PYLORI INFECTION ON GASTRIC AICD SECRETION

幽门螺杆菌感染对胃酸分泌的影响

• 批准号: 08670577
• 负责人: KANEKO Eizo
• 金额: $ 1.41万
• 依托单位: HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08670577/
• 关键词: Gastric juice pH; gastrin; Helicobacter pylori; 胃炎; 胃酸分泌; 消化性潰瘍; IL-1 beta; ヘリコバクター・ピロリ; プロトンポンプ

Background : How Helicobacter pylori infection affects gastric acid secretion is still unclear.Methods : Gastric juice pH and a mmonia concentrationing astric juice, serum gastrin level, and grade of gastritis according to the Sydney System were determined for patients with gastric ulcer (GU) and duodenal ulcer (DU) before and a ftertreatment with lansoprazole and a moxicillin, and results were compared with H.pylori-negative controls.Results : Scores for H.pylori-density, atrophy, metaplasia, and activity of gastritis in the corpus were higher in patients with GU,especially proximally those with located GU,than in those with DU.Gastric juice pH was significantly higher in GU patients than in DU patients and controls. After eradication of H.pylori, gastric juice pH and serum gastrin levels in both GU and DU patients were significantly decreased to control levels. In patients without eradication of H.pylori, no significant changes in those parameters were observed.Conclusions : These findings suggest that H.pylori infection and gastritis in the corpus suppress acid secretion and increase gastric juice pH,resulting in hypergastrinemia, and that eradiction of H.pylori normalizes acid secretion and serum gastrin levels.

背景资料：方法：对胃溃疡（GU）和十二指肠溃疡（DU）患者用兰索拉唑和阿莫西林治疗前后，测定胃液pH值、胃液氨浓度、血清胃泌素水平和胃炎程度，并与幽门螺杆菌阴性对照组进行比较。GU患者胃体幽门螺杆菌密度、萎缩、化生和活动性胃炎评分均高于DU患者，尤其是GU位于胃近端的患者。GU患者胃液pH值显著高于DU患者和对照组。幽门螺杆菌根除后，GU和DU患者的胃液pH和血清胃泌素水平均显著降低至对照水平。在没有根除幽门螺杆菌的患者中，这些参数没有显着的变化observed.Conclusions：这些研究结果表明，幽门螺杆菌感染和胃炎的身体抑制胃酸分泌，增加胃液pH值，导致高胃泌素血症，根除幽门螺杆菌正常化酸分泌和血清胃泌素水平。

项目成果

Takahisa Furuta: "Study of transmission routes of Helicobacter pylori in relation with seroprevalence of hepatitis A virus." J.Clin Microbiol.35. 1891-1893 (1997)

Takahisa Furuta：“研究幽门螺杆菌传播途径与甲型肝炎病毒血清流行率的关系。”

古田隆久 他: "血清ペプシノゲン・ガストリン値の変化よりみたH.pyloriの除菌判定" Prog.in Med.15(9). 240-244 (1995)

Takahisa Furuta 等人：“根据血清胃蛋白酶原和胃泌素水平的变化确定幽门螺杆菌的根除”Prog.in Med.15(9) (1995)。

Takahisa Furuta: "Seroprevalances of Helicobacter pylori and hepatitis A virus." Am.J.Gastroenterol.2. 281 (1998)

Takahisa Furuta：“幽门螺杆菌和甲型肝炎病毒的血清阳性率。”

伊藤 剛: "消化管機能と24時間pHモニタリング" (株)医薬ジャーナル社, 146 (1997)

伊藤刚：“胃肠功能和24小时pH监测” Iyaku Journal Co., Ltd.，146（1997）

Furuta T et al: "Quantitative study of H.pylori in gastric muws by competitive PCR using synthetic DNA fragments" J Clin Microbiol. 34(10). 2421-2425 (1996)

Furuta T 等人：“使用合成 DNA 片段通过竞争性 PCR 对胃粘膜中的幽门螺杆菌进行定量研究”J Clin Microbiol。