Clinical Application of Visual Event-relatel Potentials using figures and letters

摘要为了明确帕金森综合征中是否存在特征性的事件相关电位（ERPs）变化，我们研究了8例进行性核上性麻痹（PSP）患者、10例皮质基底变性（CBD）患者、9例纹状体变性（SND）患者和16例特发性帕金森病（PD）患者，每组平均病程小于5年。采用视觉古怪范式和延迟匹配范式（s1 - s2）诱发erp。各组与相应年龄匹配正常对照组的erp和RT进行比较，并相互比较。在PSP中，P300振幅明显降低，而在CBD中，P300潜伏期在古怪任务和S1-S2任务中均延长。SND组和PD组在古怪任务过程中均未发现P300异常。然而，在S1-S2任务中，PD组发现N200显著延迟和P300幅度降低，而SND组没有。PSP组和CBD组的平均RT明显长于其他两组。这些结果与年龄无关。在两种任务中同时测量erp和RT可能为促进帕金森综合征在临床和神经放射学标准下的诊断提供有用的补充信息。

Abstract In order to clarify whether there are characteristic changes of event-related potentials (ERPs) in parkinsonian syndromes, we studied 8 patients with progressive supranuclear palsy (PSP), 10 patients with corticobasal degeneration (CBD), 9 patients with striatonigral degeneration (SND), and 16 patients with idiopathic Parkinson's disease (PD) with a mean duration of illness of less than five years in each group. A visual oddball paradigm and a delayed matching (S 1-S2) paradigm were employed to elicit ERPs. ERPs and reaction time (RT) in each group were compared with those in the corresponding age-matched normal control group and to each other. In PSP, P300 amplitude was markedly reduced while in CBD P300 latency was prolonged during both the oddball and the S1-S2 task. No P300 abnormalities were found in the SND group or the PD group during the oddball task. However, significantly delayed N200 and reduced P300 amplitude during the S1-S2 task were found in PD but not in SND.The mean RT in the PSP and the CBD group was significantly longer than in the other two groups. These results were not due to age. Simultaneous measurement of ERPs and RT during two kinds of tasks may yield useful supplementary information in facilitating diagnosis of parkinsonian syndromes under clinical and neuroradiological criteria.