Production of quantitative higher brain function assessing system using visual event related potentials and positron emission tomography

近20年来，人们一直在使用世界卫生组织定义的国际损伤、残疾和障碍分类框架来研究脑卒中和脊髓损伤等神经系统疾病中的损伤、残疾和障碍之间的关系。帕金森病中的这些关系很少在统计学基础上进行研究。为了确定帕金森病患者的损伤、残疾、障碍、主要照顾者的护理负担、经济费用、事件相关电位和脑血流量之间的关系，我们对24名患者和14名照顾者的这些参数进行了定量评估。通过运动和自主神经损伤的症状评估以及使用长谷川痴呆量表修订版、简易精神状态检查和抑郁自评量表的神经心理学评估来测量损伤。残疾程度用Hoehn和Yahr量表、Barthel指数和老年日常生活活动能力来衡量。采用克雷格残疾评估和报告技术测量残疾。得分的照顾负担的主要照顾者的身体和心理社会方面。通过测量视觉事件相关电位和局部脑血流量来研究神经生理功能障碍。运动、认知和自主神经功能障碍、残疾和残疾彼此显著相关。帕金森病患者的主要照顾者的护理负担、经济费用、视觉事件相关电位和局部脑血流量与损伤、残疾和残疾显著相关。帕金森病的症状、神经心理学、电生理学和神经影像学评估被证明有助于预测他们的生活质量、家庭护理负担和经济支出。

For these twenty years, the relationships among impairment, disability, and handicap in neurological diseases such as stroke and spinal cord injury have been studied using the framework of international classification of impairment, disability, and handicap, defined by World Health Organization. Those relationships in Parkinson's disease have rarely been studied on statistical basis. To identify the relationships among impairment, disability, handicap, burden of care on a principal caregiver, economic expenses, event-related potentials, and cerebral blood flow in patients with Parkinson's disease, we made quantitative evaluations on these parameters in 24 patients and 14 caregivers. Impairment was measured by symptomatic assessment for motor and autonomic impairments and neuropsychological assessment using Hasegawa dementia scale revised, mini mental state examination, and self-rating depression scale. Disability was measured by Hoehn and Yahr scale, Barthel index, and geriatric activity of daily living. Handicap was measured by Craig handicap assessment and reporting technique. Scores for burden of care measured on a principal caregiver had physical and psychosocial aspects. Neurophysiological dysfunction was studied by measuring visual event-related potentials and regional cerebral blood flow. Motor, cognitive, and autonomic impairments, disability, and handicap significantly correlated to each other. Burden of care on a principal caregiver, economic expenses, visual event-related potentials, and regional cerebral blood flow in patients with Parkinson's disease were significantly correlated with impairment, disability, and handicap. Symptomatic, neuropsychological, electrophysiological, and neuroimaging evaluations in Parkinson's disease proved useful to predict their quality of life, burden of care on their families, and economic expenses.