THE NOVEL HIGH-RESOLUTION DOPPLER METHOD FOR REGIONAL ATHERO-ARTERIOSCLEROSIS AND ITS APPLICARION TO THE GROUP MEDICAL EXAMINATION

在本项目中，我们基于微米级分钟运动速度的新分析原理，开发了动脉粥样硬化局部病理改变的无创高分辨率诊断方法。本方法是为群体医学检查的临床应用而构建的。即每个人完成的评估时间<10min。此外，我们还为东北电力公司的16,000名员工构建了在线计算机系统。我们探讨了动脉粥样硬化危险因素与颈动脉病变改变的关系。以下是本次检查的结果：我们可以精确地评估动脉壁厚度的局部硬化变化，沿心脏周期的瞬时壁厚变化，不仅是整个壁的适当弹性刚度，而且从管腔表面隔壁每10微米厚度层的适当弹性刚度。这些评价在常规诊断方法中是不可能的。2 .动脉硬化的最早变化是固有壁的改变，而不是以往报道的管壁增厚。利用这种新方法，我们可以评估动脉粥样硬化斑块内部的物理性质。动脉粥样硬化斑块的内部成分在相对较短的几周内发生了变化。动脉粥样硬化斑块的稳定性是急性冠脉综合征发生的关键因素。这里开发的非侵入性多普勒技术提供了斑块稳定性的信息，这些信息来自斑块上每层的粘滞值。应用这种新颖的多普勒方法进行群体临床检查，将明确药物治疗对局部动脉粥样硬化病变的治疗效果以及如何或何时开始治疗。

In this project, we developed non-invasive high-resolition diagnostic method for regional pathological change of the arterio-atherosclerosis, which based on the novel analytical principle of the micron-order minute motion velocity at the cardiovacular tissue. The method has been constructed for the clinical use of the group medical examination. That is, the evaluation completed <10min per person. Moreover, we constructed the on-line computer system for 16,000 workers of the Tohoku Electric Company. We examined the relation ship of the areteriosclerotc risk factors and the change in the pathological lesion at the carotid artery.Followings are the results of this examination ;1.We can precisely evaluate the regional arteriosclerotic change of the arterial wall thickness, the instantaneous change in the wall thickness along the cardiac cycle, proper elastic stiffiness not only of entire wall but also of each tenth-micron thickness layr across the wall from luminal surface. These evaluation was impossible in routine, conventional diagnostic method.2.The earliest change of the arteriosclerosis was the change in the proper wall, not the thickening of the wall inthe previous report.3.Using this novel method, we can evaluate the physical nature inside the atheromatous plaque. That is the stiffness of the firous cap and/or the lipid pool included by the cap.The inner composition of the atheromatous plaque changed relatively short period of several weeks.The stabiblity of the ateromatous plaque was strongly suggested to be the key factor of the acuke coronary syndrome. The non-invasive doppler technoque developed here supplies the information on this stability of the plaque from the viscoeastic value at each layr across the plaque. The application of this novel doppler method for the group clinical examination would clarify the efficacy of the treatment of the medical therapy on the regional atheromatous lesion and how or when the theraspy should be started.