Effects of sex steroids on growth of rats

[AIM]上一项研究建议，即通过长量高量高的胰岛素样生长因子（IGF） -1个水平的男性老鼠，增加了两个体重高和IGF-1个水平的女性老鼠，增加了女性老鼠的体重增益和IGF-1个水平。我们推测了周内性Gonadal类固醇和升高的Gonadatropins可能会影响生长和生长激素（GH） /IGF-1轴。本研究的目的是评估Hypogonadropic Gonadal抑制自新生儿期对身体生长和血清IGF-1水平的影响。[材料和方法]内源性矮鼠被用作完整GH缺陷（GHD）模型，而Sprague-Dawlry （SD）大鼠被用作控制。Gonadotropin释放激素模拟（GnRHa ：Leuproide acetate Depot，2毫克/千克）被管理为每3周的亚切切实际。治疗瓦州 ... More 在出生后48小时内开始，并在年龄15周终止。身体重量、血清睾丸激素（T）或雌二醇（E2）和IGF-1已被评估，并与经盐水处理的大鼠相比有影响。[Results]血清T或E2被GnRH治疗显著减少。15岁的身体重量在雄性老鼠的两条线之间并不不同（saline vs GnRHa ; 551（]SY.+-）。（43 vs 561）SY.+- [）27 g in SD rats， 88（]SY.+-。[15] 15 vs.91（SY.+-）[）12 g in GHD rats）。在普通的，市场上较大的身体重量在GnRHa组观察到SD大鼠（285（）SY.+-。[351][351]SY.+- [）31克， p<0.01），但不在GHD大鼠中（79（]SY.+-）。（15比79比16）。血清IGF-1在两个男性的两只老鼠之间并不不同（957 - 173对976（]SY.+-）。[）SD大鼠97纳克/毫升， 10.3（]SY.+-。[1] 1.0 vs 11.5（]SY.+-）[）1.3 ng/ml在GHD大鼠中）和女性（460（）SY.+-。[167 vs.534]SY.+- [）SD大鼠74纳克/毫升， 11.6（]SY.+-。[3.1 vs 11.0]SY.+- [））1.8 ng/ml in GHD rats）。[摘要]这些数据指标表明，GnRHa诱导的Gonadal Suppression并不影响男性老鼠的身体生长或IGF-1，而当抑制的Gonadotropin-estrogen axis被发现在增加的身体重量没有改变在女性老鼠循环IGF-1水平中，这种影响似乎通过GH被调节。Less（低）

*EFFECTS OF LONG-TERM GONADOTROPIN-RELEASING HORMONE ANALOGUE TREATMENT ON SOMATIC GROWTE AND CIRCULATING INSULIN-LIKE GROWTH FACTOR-1 LEVELS IN THE GROWTH HOIRMONE DEFICIENT RAT*[AIM] Previous studies suggest that gonadectomy lead to slight reduction of body weight gain with increased or unchanged insulin-like growth factor (IGF) -1 levels in male rats, and increased both weight gain and IGF-1 levels in female rats. We speculate that perinatal gonadal steroids and elevated gonadatropins may affect growth and the growth hormone (GH) /IGF-1 axis. This study was designed to evaluate the effects of hypogonadotropic gonadal suppression since neonatal period on somatic growth and serum IGF-1 levels in rats.[MATERIALS and METHODS] Spontaneous dwarf rat was used as a model of complete GH deficiency (GHD), and Sprague-Dawlry (SD) rat was used as control.Gonadotropin-releasing hormone analogue (GnRHa : Leuprolide acetate depot, 2mg/kg) was administered subcutaneously every 3 weeks. Treatment wa … More s started within 48 hours after birth and terminated at 15 weeks of age. Body weight, serum testosterone (T)or estradiol (E2), and IGF-1 were evaluated, and effects were compared with saline treated rats.[RESULTS] Serum T or E2 were significantly reduced by the GnRHa treatment. Body weight at 15 was not different between the groups in both lines of male rats (saline vs GnRHa ; 551(]SY.+-。[)43 vs 561(]SY.+-。[)27g in SD rats, 88(]SY.+-。[))15 vs 91(]SY.+-。[)12g in GHD rats). While in famale, markedly greater body weight in the GnRHa group was observed in SD rats (285(]SY.+-。[)7 vs 351(]SY.+-。[))31g, p<0.01), but not in GHD rats (79(]SY.+-。[)15 vs 79ア16g). Serum IGF-1 was not different between the groups in both rats of both male (957 ア173 vs 976(]SY.+-。[)97ng/ml in SD rats, 10.3(]SY.+-。[)1.0 vs 11.5(]SY.+-。[)1.3ng/ml in GHD rats) and female (460(]SY.+-。[)167 vs 534(]SY.+-。[)74ng/ml in SD rats, 11.6(]SY.+-。[)3.1 vs 11.0(]SY.+-。[))1.8ng/ml in GHD rats).[SUMMARY] These data indicate that GnRHa induced gonadal suppression did not affect somatic growth or IGF-1 in male rats, while suppressed gonadotropin-estrogen axis resulted in increased body weight without changes in circulating IGF-1 levels in female rats, and this effect appears to be mediated through GH. Less